Amanda Enstrom
Overview
Explore the profile of Amanda Enstrom including associated specialties, affiliations and a list of published articles.
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11
Citations
447
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Recent Articles
1.
Davies R, Peng S, Lickliter J, McLendon K, Enstrom A, Chunyk A, et al.
Clin Transl Sci
. 2024 Nov;
17(11):e70055.
PMID: 39494621
Therapeutic agents targeting the tumor necrosis factor (TNF) superfamily cytokines B-cell activating factor (BAFF, BLyS) and/or A PRoliferation Inducing Ligand (APRIL) have demonstrated clinical effectiveness in multiple autoimmune diseases, such...
2.
Cavalcante L, Chandana S, Lakhani N, Enstrom A, LeBlanc H, Schmalz J, et al.
J Immunother Cancer
. 2024 Aug;
12(8).
PMID: 39142718
Engagement of programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) can interfere with the CD28 signaling requisite for T-cell activation. While immune checkpoint inhibitors (ICIs) can relieve this suppression,...
3.
Davar D, Cavalcante L, Lakhani N, Moser J, Millward M, McKean M, et al.
J Immunother Cancer
. 2024 Aug;
12(8).
PMID: 39097413
Background: Davoceticept (ALPN-202) is an Fc fusion of a CD80 variant immunoglobulin domain designed to mediate programmed death-ligand 1 (PD-L1)-dependent CD28 co-stimulation while inhibiting the PD-L1 and cytotoxic T-lymphocyte-associated antigen...
4.
Hassan R, Alley E, Kindler H, Antonia S, Jahan T, Honarmand S, et al.
Clin Cancer Res
. 2019 Jul;
25(19):5787-5798.
PMID: 31263030
Purpose: Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with poor prognosis. CRS-207 is a live-attenuated engineered to express mesothelin, a tumor-associated antigen highly expressed in MPM. CRS-207 induces...
5.
Le D, Picozzi V, Ko A, Wainberg Z, Kindler H, Wang-Gillam A, et al.
Clin Cancer Res
. 2019 May;
25(18):5493-5502.
PMID: 31126960
Purpose: Limited options exist for patients with advanced pancreatic cancer progressing after 1 or more lines of therapy. A phase II study in patients with previously treated metastatic pancreatic cancer...
6.
Enstrom A, Onore C, Hertz-Picciotto I, Hansen R, Croen L, Van de Water J, et al.
Am J Biochem Biotechnol
. 2016 Oct;
4(2):114-120.
PMID: 27688738
Interleukin-23 (IL-23) is a survival factor for a newly described population of T lymphocytes, namely Th-17 cells, that secrete IL-17, tumor necrosis factor- alpha (TNFα) and IL-6. It has been...
7.
Enstrom A, Onore C, Tarver A, Hertz-Picciotto I, Hansen R, Croen L, et al.
Am J Biochem Biotechnol
. 2016 Sep;
4(2):121-129.
PMID: 27683277
Brain-derived neurotrophic factor (BDNF) is critical for neuronal differentiation and synaptic development. BDNF is also implicated in the development of psychological disorders including depression, bipolar disorder and schizophrenia. Previously, elevated...
8.
Onore C, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, Van de Water J, et al.
J Neuroimmunol
. 2009 Oct;
216(1-2):126-9.
PMID: 19800697
A potential role for T(H)17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular...
9.
Enstrom A, Krakowiak P, Onore C, Pessah I, Hertz-Picciotto I, Hansen R, et al.
Brain Behav Immun
. 2009 Jan;
23(3):389-95.
PMID: 19136055
Accumulating evidence indicates that immune dysfunction is associated with autism disorders in a significant subset of children. Previous reports have shown abnormal immunoglobulin (Ig) levels, including an increased presence of...
10.
Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen L, et al.
J Neuroimmunol
. 2008 Sep;
204(1-2):149-53.
PMID: 18762342
Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. There is evidence of both immune dysregulation and autoimmune phenomena in...