Amanda Cirello
Overview
Explore the profile of Amanda Cirello including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
12
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0
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Recent Articles
1.
Perino S, Moreau B, Freda J, Cirello A, White B, Quinn J, et al.
Mol Cancer Ther
. 2020 Jun;
19(8):1613-1622.
PMID: 32499300
The PI3K pathway is considered a master regulator for cancer due to its frequent activation, making it an attractive target for pharmacologic intervention. While substantial efforts have been made to...
2.
Forkuo A, Ansah C, Pearson D, Gertsch W, Cirello A, Amaral A, et al.
BMC Pharmacol Toxicol
. 2017 Dec;
18(1):84.
PMID: 29273084
Background: This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and...
3.
Gunduz M, Argikar U, Kamel A, Colizza K, Bushee J, Cirello A, et al.
Drug Metab Dispos
. 2012 Aug;
40(11):2074-80.
PMID: 22851614
In vitro metabolite identification and GSH trapping studies in human liver microsomes were conducted to understand the bioactivation potential of compound 1 [2-(6-(4-(4-(2,4-difluorobenzyl)phthalazin-1-yl)piperazin-1-yl)pyridin-3-yl)propan-2-ol], an inhibitor of the Hedgehog pathway. The...