Alyxandria M Schubert
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Explore the profile of Alyxandria M Schubert including associated specialties, affiliations and a list of published articles.
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16
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1207
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Recent Articles
1.
Berkson J, Wate C, Allen G, Schubert A, Dunbar K, Coryell M, et al.
Nat Commun
. 2024 Apr;
15(1):2993.
PMID: 38582763
Bacteriophage therapy is a promising approach to address antimicrobial infections though questions remain regarding the impact of the immune response on clinical effectiveness. Here, we develop a mouse model to...
2.
Lesniak N, Schubert A, Flynn K, Leslie J, Sinani H, Bergin I, et al.
mBio
. 2022 Jul;
13(4):e0118322.
PMID: 35856563
The severity of Clostridioides difficile infections (CDI) has increased over the last few decades. Patient age, white blood cell count, and creatinine levels as well as C. difficile ribotype and...
3.
Lesniak N, Schubert A, Sinani H, Schloss P
mSphere
. 2021 May;
6(3).
PMID: 33952668
The gut bacterial community prevents many pathogens from colonizing the intestine. Previous studies have associated specific bacteria with clearing colonization across different community perturbations. However, those bacteria alone have been...
4.
Smith A, Foss E, Zhang I, Hastie J, Giordano N, Gasparyan L, et al.
PLoS One
. 2019 Sep;
14(9):e0223025.
PMID: 31560732
Clostridium difficile (Cd) infection (CDI) typically occurs after antibiotic usage perturbs the gut microbiota. Mucosa-associated invariant T cells (MAIT) are found in the gut and their development is dependent on...
5.
Chatterjee A, Johnson C, Luong P, Hullahalli K, McBride S, Schubert A, et al.
Infect Immun
. 2019 Apr;
87(6).
PMID: 30936157
is a human intestinal pathobiont with intrinsic and acquired resistance to many antibiotics, including vancomycin. Nature provides a diverse and virtually untapped repertoire of bacterial viruses, or bacteriophages (phages), that...
6.
Germinant Synergy Facilitates Clostridium difficile Spore Germination under Physiological Conditions
Kochan T, Shoshiev M, Hastie J, Somers M, Plotnick Y, Gutierrez-Munoz D, et al.
mSphere
. 2018 Sep;
3(5).
PMID: 30185513
is a Gram-positive obligate anaerobe that forms spores in order to survive for long periods in the unfavorable environment outside a host. is the leading cause of nosocomial infectious diarrhea...
7.
Kula A, Saelens J, Cox J, Schubert A, Travisano M, Putonti C
Sci Rep
. 2018 May;
8(1):8350.
PMID: 29844443
Viruses rely upon their hosts for biosynthesis of viral RNA, DNA and protein. This dependency frequently engenders strong selection for virus genome compatibility with potential hosts, appropriate gene regulation and...
8.
Kochan T, Somers M, Kaiser A, Shoshiev M, Hagan A, Hastie J, et al.
PLoS Pathog
. 2017 Jul;
13(7):e1006443.
PMID: 28704538
Clostridium difficile (C. difficile) is an anaerobic gram-positive pathogen that is the leading cause of nosocomial bacterial infection globally. C. difficile infection (CDI) typically occurs after ingestion of infectious spores...
9.
Schubert A, Sinani H, Schloss P
mBio
. 2015 Jul;
6(4):e00974.
PMID: 26173701
Unlabelled: Perturbations to the gut microbiota can result in a loss of colonization resistance against gastrointestinal pathogens such as Clostridium difficile. Although C. difficile infection is commonly associated with antibiotic...
10.
Kopliku F, Schubert A, Mogle J, Schloss P, Young V, Aronoff D
Anaerobe
. 2014 Dec;
32:34-36.
PMID: 25481351
Clostridium septicum is an uncommon cause of severe infection. Real-time PCR against the C. septicum-specific alpha-toxin gene (csa) was used to estimate the prevalence of this microbe in human stool...