Alvin Wei Tian Ng
Overview
Explore the profile of Alvin Wei Tian Ng including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
2253
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0
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Recent Articles
1.
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Anticevic I, Otten C, et al.
Cell
. 2024 Sep;
187(20):5698-5718.e26.
PMID: 39265577
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of...
2.
Ng A, McClurg D, Wesley B, Zamani S, Black E, Miremadi A, et al.
Nat Commun
. 2024 May;
15(1):4533.
PMID: 38806493
No abstract available.
3.
Ng A, McClurg D, Wesley B, Zamani S, Black E, Miremadi A, et al.
Nat Commun
. 2024 May;
15(1):4074.
PMID: 38744814
Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood....
4.
Black E, Ococks E, Devonshire G, Ng A, ODonovan M, Malhotra S, et al.
Gut
. 2023 Nov;
73(5):729-740.
PMID: 37989565
Objective: Whether gastric metaplasia (GM) of the oesophagus should be considered as Barrett's oesophagus (BO) is controversial. Given concern intestinal metaplasia (IM) may be missed due to sampling, the UK...
5.
Luebeck J, Ng A, Galipeau P, Li X, Sanchez C, Katz-Summercorn A, et al.
Nature
. 2023 Apr;
616(7958):798-805.
PMID: 37046089
Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with cancer. At present, it is...
6.
Toh M, Wong E, Wong S, Ng A, Loo L, Chow P, et al.
Gastroenterology
. 2023 Feb;
164(5):766-782.
PMID: 36738977
Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC develops in genetically susceptible individuals who are exposed to risk factors, especially in the presence of liver cirrhosis....
7.
Alexandrov L, Kim J, Haradhvala N, Huang M, Ng A, Wu Y, et al.
Nature
. 2023 Jan;
614(7948):E41.
PMID: 36697836
No abstract available.
8.
Ng A, Contino G, Killcoyne S, Devonshire G, Hsu R, Abbas S, et al.
Commun Biol
. 2022 Apr;
5(1):335.
PMID: 35396535
Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed structural...
9.
Wu Y, Chua E, Ng A, Boot A, Rozen S
Sci Rep
. 2022 Jan;
12(1):390.
PMID: 35013428
Mutational signatures are characteristic patterns of mutations generated by exogenous mutagens or by endogenous mutational processes. Mutational signatures are important for research into DNA damage and repair, aging, cancer biology,...
10.
Ococks E, Sharma S, Ng A, Aleshin A, Fitzgerald R, Smyth E
Gastroenterology
. 2021 Jul;
161(5):1705-1708.e2.
PMID: 34284036
No abstract available.