Alvaro Valin
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Explore the profile of Alvaro Valin including associated specialties, affiliations and a list of published articles.
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10
Citations
258
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Recent Articles
1.
Valin A, Del Rey M, Municio C, Usategui A, Romero M, Fernandez-Felipe J, et al.
BMC Mol Cell Biol
. 2020 Oct;
21(1):74.
PMID: 33126846
Introduction: The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts...
2.
Del Rey M, Valin A, Usategui A, Ergueta S, Martin E, Municio C, et al.
Immun Ageing
. 2019 Nov;
16:29.
PMID: 31708994
Background: Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence in human...
3.
Del Rey M, Valin A, Usategui A, Garcia-Herrero C, Sanchez-Arago M, Cuezva J, et al.
Sci Rep
. 2017 Jun;
7(1):3644.
PMID: 28623342
Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O environments, elevated rates of glycolysis support critical cellular mechanisms such as cell...
4.
Valin A, Pablos J
Biomolecules
. 2015 Oct;
5(4):2723-57.
PMID: 26501341
Chronic inflammation is a common process connecting pathologies that vary in their etiology and pathogenesis such as cancer, autoimmune diseases, and infections. The response of the immune system to tissue...
5.
Valin A, Gill G
Cell Cycle
. 2013 May;
12(12):1828-34.
PMID: 23676218
The transition of paused RNA polymerase II into productive elongation is a highly dynamic process that serves to fine-tune gene expression in response to changing cellular environments. We have recently...
6.
Valin A, Ouyang J, Gill G
Mol Cell Biol
. 2013 Feb;
33(8):1582-93.
PMID: 23401853
Like that of many protein-coding genes, expression of the p21(CIP1) cell cycle inhibitor is regulated at the level of transcription elongation. While many transcriptional activators have been shown to stimulate...
7.
Ramos B, Valin A, Sun X, Gill G
Mol Cell Neurosci
. 2009 Jun;
42(2):152-9.
PMID: 19555762
Regulation of neuronal gene expression is critical to establish functional connections in the mammalian nervous system. The transcription factor Sp4 regulates dendritic patterning during cerebellar granule neuron development by limiting...
8.
Valin A, Cook J, Ross S, Saklad C, Gill G
Biochim Biophys Acta
. 2009 May;
1789(3):204-11.
PMID: 19437621
Cyclin-dependent kinase 5 (cdk5) activity is critical for development and function of the nervous system. Cdk5 activity is dependent on association with the regulators p35 and p39 whose expression is...
9.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
Mol Cell
. 2009 Apr;
34(2):145-54.
PMID: 19394292
Posttranslational modification of transcription factors by the small ubiquitin-related modifier SUMO is associated with transcriptional repression, but the underlying mechanisms remain incompletely described. We have identified binding of the LSD1/CoREST1/HDAC...
10.
Ouyang J, Valin A, Gill G
Methods Mol Biol
. 2008 Dec;
497:141-52.
PMID: 19107415
Post-translational modification by SUMO is an important mechanism to regulate transcription. Sumoyla-tion has diverse effects on substrate activity, but in most cases reported to date sumoylation of transcription factors correlated...