Alok R Singh
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Explore the profile of Alok R Singh including associated specialties, affiliations and a list of published articles.
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15
Citations
455
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Recent Articles
1.
Thaker Y, Rivera I, Pedros C, Singh A, Rivero-Nava L, Zhou H, et al.
Front Oncol
. 2022 Jun;
12:884196.
PMID: 35664753
Therapeutic blockade of the CD47/SIRPα axis by small molecules or monoclonal antibodies (mAbs) is a proven strategy to enhance macrophages-mediated anti-tumor activity. However, this strategy has been hampered by elevated...
2.
Joshi S, Liu K, Zulcic M, Singh A, Skola D, Glass C, et al.
Mol Cancer Ther
. 2020 Jan;
19(3):755-764.
PMID: 31974273
Macrophages (MΦ) play a critical role in tumor growth, immunosuppression, and inhibition of adaptive immune responses in cancer. Hence, targeting signaling pathways in MΦs that promote tumor immunosuppression will provide...
3.
Joshi S, Singh A, Liu K, Pham T, Zulcic M, Skola D, et al.
Mol Cancer Ther
. 2019 Apr;
18(6):1036-1044.
PMID: 31018997
Macrophages (MΘs) are key immune infiltrates in solid tumors and serve as major drivers behind tumor growth, immune suppression, and inhibition of adaptive immune responses in the tumor microenvironment (TME)....
4.
Erdreich-Epstein A, Singh A, Joshi S, Vega F, Guo P, Xu J, et al.
Oncotarget
. 2017 Sep;
8(32):52193-52210.
PMID: 28881723
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic integrin αβ was increased in high-risk metastatic (stage 4) NB compared with...
5.
Joshi S, Singh A, Wong S, Zulcic M, Jiang M, Pardo A, et al.
PLoS One
. 2017 Aug;
12(8):e0182851.
PMID: 28817691
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by cellular phenotype alterations and deposition of extracellular matrix proteins. The alternative activation of macrophages in the lungs has been...
6.
Andrews F, Singh A, Joshi S, Smith C, Morales G, Garlich J, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(7):E1072-E1080.
PMID: 28137841
is a major cancer driver but is documented to be a difficult therapeutic target itself. Here, we report on the biological activity, the structural basis, and therapeutic effects of the...
7.
Singh A, Joshi S, Burgoyne A, Sicklick J, Ikeda S, Kono Y, et al.
Mol Cancer Ther
. 2016 Aug;
15(11):2553-2562.
PMID: 27496136
Deregulated PI3K/AKT/mTOR, Ras/Raf/MAPK, and c-Myc signaling pathways are of prognostic significance in hepatocellular carcinoma (HCC). Sorafenib, the only drug clinically approved for patients with advanced HCC, blocks the Ras/Raf/MAPK pathway...
8.
Singh A, Joshi S, Zulcic M, Alcaraz M, Garlich J, Morales G, et al.
PLoS One
. 2016 Mar;
11(3):e0150836.
PMID: 26938241
Sonic hedgehog (SHH) medulloblastoma (MB) subtype is driven by a proliferative CD15+ tumor propagating cell (TPC), also considered in the literature as a putative cancer stem cell (CSC). Despite considerable...
9.
Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma
Joshi S, Singh A, Durden D
Cancer Chemother Pharmacol
. 2015 Jan;
75(3):595-608.
PMID: 25578041
Purpose: SF1126 is a vascular-targeted pan-PI-3K inhibitor prodrug with antitumor and antiangiogenic activity and has completed phase I clinical trial in solid tumors and B-cell malignancies. In this study, we...
10.
Singh A, Joshi S, George E, Durden D
Cancer Cell Int
. 2014 Nov;
14(1):105.
PMID: 25425962
Background: Growth factor mediated activation of RAS-MAP-kinase and PI3-kinase-AKT pathways are critical for the pathogenesis of glioblastoma. The attenuation of PI3-kinase/AKT signaling will be effective in regulating the tumorigenic phenotypes...