Allende Miguelez-Crespo
Overview
Explore the profile of Allende Miguelez-Crespo including associated specialties, affiliations and a list of published articles.
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3
Citations
6
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Recent Articles
1.
Ivatt L, Paul M, Miguelez-Crespo A, Hadoke P, Bailey M, Morgan R, et al.
Cardiovasc Diabetol
. 2025 Jan;
24(1):39.
PMID: 39856754
Background: Obesity, a major risk factor for cardiovascular disease (CVD), is associated with hypertension and vascular dysfunction. Perivascular adipose tissue (PVAT), a metabolically active tissue surrounding blood vessels, plays a...
2.
Boyle L, Miguelez-Crespo A, Paul M, Villalobos E, Toews J, Ivatt L, et al.
Nat Commun
. 2025 Jan;
16(1):545.
PMID: 39788946
Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly...
3.
Villalobos E, Miguelez-Crespo A, Morgan R, Ivatt L, Paul M, Simpson J, et al.
J Endocrinol
. 2024 Jun;
262(2).
PMID: 38829241
Glucocorticoids modulate glucose homeostasis, acting on metabolically active tissues such as liver, skeletal muscle, and adipose tissue. Intracellular regulation of glucocorticoid action in adipose tissue impacts metabolic responses to obesity....
4.
Toews J, Philippe T, Hill L, Dordevic M, Miguelez-Crespo A, Homer N, et al.
Endocrinology
. 2022 Sep;
163(11).
PMID: 36112420
Encoded by SerpinA6, plasma corticosteroid-binding globulin (CBG) transports glucocorticoids and regulates their access to cells. We determined how CBG influences plasma corticosterone and adrenal development in rats during the pubertal...
5.
Bell R, Villalobos E, Nixon M, Miguelez-Crespo A, Murphy L, Fawkes A, et al.
Mol Metab
. 2021 Mar;
48:101225.
PMID: 33785425
Objective: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may...