Allan Jacobson
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Explore the profile of Allan Jacobson including associated specialties, affiliations and a list of published articles.
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66
Citations
5012
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Recent Articles
11.
Mangkalaphiban K, He F, Ganesan R, Wu C, Baker R, Jacobson A
PLoS Genet
. 2021 Apr;
17(4):e1009538.
PMID: 33878104
Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide...
12.
Luban J, Sattler R, Muhlberger E, Graci J, Cao L, Weetall M, et al.
Virus Res
. 2020 Nov;
292:198246.
PMID: 33249060
The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for therapeutics that inhibit the SARS-COV-2 virus and suppress the fulminant inflammation characteristic of advanced illness. Here, we describe...
13.
Wu C, Roy B, He F, Yan K, Jacobson A
Cell Rep
. 2020 Nov;
33(7):108399.
PMID: 33207198
Multiple factors influence translation termination efficiency, including nonsense codon identity and immediate context. To determine whether the relative position of a nonsense codon within an open reading frame (ORF) influences...
14.
Luban J, Sattler R, Muhlberger E, Graci J, Cao L, Weetall M, et al.
bioRxiv
. 2020 Aug;
PMID: 32793904
The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for therapeutics that inhibit the SARS-CoV-2 virus and suppress the fulminant inflammation characteristic of advanced illness. Here, we describe...
15.
Zeidan Q, He F, Zhang F, Zhang H, Jacobson A, Hinnebusch A
PLoS Genet
. 2019 Jul;
15(7):e1008299.
PMID: 31335872
[This corrects the article DOI: 10.1371/journal.pgen.1007806.].
16.
Ng M, Zhang H, Weil A, Singh V, Jamiolkowski R, Baradaran-Heravi A, et al.
ACS Med Chem Lett
. 2019 Jan;
9(12):1285-1291.
PMID: 30613341
Nonsense suppressors (NonSups) induce "readthrough", i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent polypeptide. Prior readthrough measurements utilized...
17.
Ganesan R, Leszyk J, Jacobson A
Methods
. 2018 Dec;
155:58-67.
PMID: 30593864
Ribosomes associated with nonsense-mediated decay factors Upf1, Upf2, or Upf3 were purified by immunoprecipitation, and enrichment and stoichiometry of Upf factors and ribosomal proteins were analyzed by western blot and...
18.
Zeidan Q, He F, Zhang F, Zhang H, Jacobson A, Hinnebusch A
PLoS Genet
. 2018 Dec;
14(12):e1007806.
PMID: 30532217
Scd6 protein family members are evolutionarily conserved components of translationally silent mRNA granules. Yeast Scd6 interacts with Dcp2 and Dhh1, respectively a subunit and a regulator of the mRNA decapping...
19.
He F, Celik A, Wu C, Jacobson A
Elife
. 2018 Dec;
7.
PMID: 30520724
The Dcp1-Dcp2 decapping enzyme and the decapping activators Pat1, Dhh1, and Lsm1 regulate mRNA decapping, but their mechanistic integration is unknown. We analyzed the gene expression consequences of deleting or...
20.
He F, Celik A, Baker R, Jacobson A
Methods Enzymol
. 2018 Dec;
612:147-181.
PMID: 30502940
Contemporary high-throughput sequencing methods, notably RNA-Seq, permit the systematic identification and characterization of transcripts whose levels change significantly in response to altered biological states. We have described methods for the...