Alka C Veerisetty
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Explore the profile of Alka C Veerisetty including associated specialties, affiliations and a list of published articles.
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14
Citations
234
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Recent Articles
1.
Hecht J, Veerisetty A, Hossain M, Patra D, Carrer M, Chiu F, et al.
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39795874
Pseudoachondroplasia (PSACH), a severe dwarfing condition characterized by impaired skeletal growth and early joint degeneration, results from mutations in cartilage oligomeric matrix protein (COMP). These mutations disrupt normal protein folding,...
2.
Hecht J, Veerisetty A, Patra D, Hossain M, Chiu F, Mobed C, et al.
Biomolecules
. 2023 Oct;
13(10).
PMID: 37892235
Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric matrix protein (COMP). The mechanisms underlying the mutant-COMP...
3.
Hecht J, Veerisetty A, Hossain M, Chiu F, Posey K
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835255
Mutations in cartilage oligomeric matrix protein (COMP) causes protein misfolding and accumulation in chondrocytes that compromises skeletal growth and joint health in pseudoachondroplasia (PSACH), a severe dwarfing condition. Using the...
4.
Hecht J, Veerisetty A, Hossain M, Patra D, Chiu F, Coustry F, et al.
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502142
Pseudoachondroplasia (PSACH), a short limb skeletal dysplasia associated with premature joint degeneration, is caused by misfolding mutations in cartilage oligomeric matrix protein (COMP). Here, we define mutant-COMP-induced stress mechanisms that...
5.
Hecht J, Veerisetty A, Wu J, Coustry F, Hossain M, Chiu F, et al.
Am J Pathol
. 2021 Jun;
191(9):1624-1637.
PMID: 34116024
Increasing numbers of people are living with osteoarthritis (OA) due to aging and obesity, creating an urgent need for effective treatment and preventions. Two top risk factors for OA, age...
6.
Hecht J, Coustry F, Veerisetty A, Hossain M, Posey K
JBMR Plus
. 2021 Mar;
5(3):e10456.
PMID: 33778324
Misfolding mutations in cartilage oligomeric matrix protein (COMP) cause it to be retained within the endoplasmic reticulum (ER) of chondrocytes, stimulating a multitude of damaging cellular responses including ER stress,...
7.
Posey K, Coustry F, Veerisetty A, Hossain M, Gambello M, Hecht J
Am J Pathol
. 2018 Dec;
189(1):132-146.
PMID: 30553437
Cartilage oligomeric matrix protein (COMP) is a large, multifunctional extracellular protein that, when mutated, is retained in the rough endoplasmic reticulum (ER). This retention elicits ER stress, inflammation, and oxidative...
8.
Coustry F, Posey K, Maerz T, Baker K, Abraham A, Ambrose C, et al.
Matrix Biol
. 2018 Jan;
67:75-89.
PMID: 29309831
Mutations in COMP (cartilage oligomeric matrix protein) cause severe long bone shortening in mice and humans. Previously, we showed that massive accumulation of misfolded COMP in the ER of growth...
9.
Posey K, Coustry F, Veerisetty A, Hossain M, Gattis D, Booten S, et al.
Mol Ther
. 2017 Feb;
25(3):705-714.
PMID: 28162960
Mutations in cartilage oligomeric matrix protein cause pseudoachondroplasia, a severe disproportionate short stature disorder. Mutant cartilage oligomeric matrix protein produces massive intracellular retention of cartilage oligomeric matrix protein, stimulating ER...
10.
Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia
Posey K, Coustry F, Veerisetty A, Hossain M, Alcorn J, Hecht J
Hum Mol Genet
. 2015 Apr;
24(14):3918-28.
PMID: 25859006
Pseudoachondroplasia (PSACH), a severe short-limb dwarfing condition, results from mutations that cause misfolding of the cartilage oligomeric matrix protein (COMP). Accumulated COMP in growth plate chondrocytes activates endoplasmic reticulum stress,...