Alistair M Jagger
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Explore the profile of Alistair M Jagger including associated specialties, affiliations and a list of published articles.
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8
Citations
92
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Recent Articles
1.
Raccosta S, Librizzi F, Jagger A, Noto R, Martorana V, Lomas D, et al.
Materials (Basel)
. 2021 Jun;
14(10).
PMID: 34063488
α1-Antitrypsin is a protease inhibitor belonging to the serpin family. Serpin polymerisation is at the core of a class of genetic conformational diseases called serpinopathies. These polymers are known to...
2.
McKimpson W, Chen Y, Irving J, Zheng M, Weinberger J, Tan W, et al.
Dev Cell
. 2021 Mar;
56(6):747-760.e6.
PMID: 33667344
Loss of insulin-secreting pancreatic β cells through apoptosis contributes to the progression of type 2 diabetes, but underlying mechanisms remain elusive. Here, we identify a pathway in which the cell...
3.
Development of a small molecule that corrects misfolding and increases secretion of Z α -antitrypsin
Lomas D, Irving J, Arico-Muendel C, Belyanskaya S, Brewster A, Brown M, et al.
EMBO Mol Med
. 2021 Jan;
13(3):e13167.
PMID: 33512066
Severe α -antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α -antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver...
4.
Jagger A, Waudby C, Irving J, Christodoulou J, Lomas D
Nat Commun
. 2020 Dec;
11(1):6371.
PMID: 33311470
Genetic mutations predispose the serine protease inhibitor α-antitrypsin to misfolding and polymerisation within hepatocytes, causing liver disease and chronic obstructive pulmonary disease. This misfolding occurs via a transiently populated intermediate...
5.
Faull S, Elliston E, Gooptu B, Jagger A, Aldobiyan I, Redzej A, et al.
Sci Adv
. 2020 Oct;
6(43).
PMID: 33087346
The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ordered aggregates. α-Antitrypsin deficiency is the archetypal serpinopathy and results from the...
6.
Laffranchi M, Elliston E, Miranda E, Perez J, Ronzoni R, Jagger A, et al.
JCI Insight
. 2020 Jul;
5(14).
PMID: 32699193
The α-1-antitrypsin (or alpha-1-antitrypsin, A1AT) Z variant is the primary cause of severe A1AT deficiency and forms polymeric chains that aggregate in the endoplasmic reticulum of hepatocytes. Around 2%-5% of...
7.
Wilson K, Jagger A, Walker M, Seinkmane E, Fox J, Kroger R, et al.
J Cell Sci
. 2018 Jan;
131(4).
PMID: 29361539
Glycans are inherently heterogeneous, yet glycosylation is essential in eukaryotes, and glycans show characteristic cell type-dependent distributions. By using an immortalized human mesenchymal stromal cell (MSC) line model, we show...
8.
Motamedi-Shad N, Jagger A, Liedtke M, Faull S, Nanda A, Salvadori E, et al.
Biochem J
. 2016 Jul;
473(19):3269-90.
PMID: 27407165
Serpins are important regulators of proteolytic pathways with an antiprotease activity that involves a conformational transition from a metastable to a hyperstable state. Certain mutations permit the transition to occur...