Alistair Boettiger
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Explore the profile of Alistair Boettiger including associated specialties, affiliations and a list of published articles.
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11
Citations
234
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Recent Articles
1.
Huang Y, Verstegen M, Tjalsma S, Krijger P, Gupta K, Park M, et al.
Genes Dev
. 2025 Jan;
39(5-6):348-363.
PMID: 39870429
Enhancers are tissue-specific regulatory DNA elements that can activate transcription of genes over distance. Their target genes most often are located in the same contact domain-chromosomal entities formed by cohesin...
2.
Bialy N, Alber F, Andrews B, Angelo M, Beliveau B, Bintu L, et al.
ArXiv
. 2024 Feb;
PMID: 38351940
Together with the molecular knowledge of genes and proteins, biological images promise to significantly enhance the scientific understanding of complex cellular systems and to advance predictive and personalized therapeutic products...
3.
Lee L, Yu H, Jia B, Jussila A, Zhu C, Chen J, et al.
Nat Commun
. 2023 Aug;
14(1):4873.
PMID: 37573342
Multiplexed DNA fluorescence in situ hybridization (FISH) imaging technologies have been developed to map the folding of chromatin fibers at tens of nanometers and up to several kilobases in resolution...
4.
Dekker J, Alber F, Aufmkolk S, Beliveau B, Bruneau B, Belmont A, et al.
Mol Cell
. 2023 Jul;
83(15):2624-2640.
PMID: 37419111
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome and the nucleus in space and time. We summarize progress by the consortium and highlight the development of technologies...
5.
Chen L, Lee J, Boettiger A
Curr Opin Genet Dev
. 2023 Feb;
79:102023.
PMID: 36854248
In the past two years, approaches relying on high-resolution microscopy and live-cell imaging have increasingly contributed to our understanding of the 3D genome organization and its importance for transcriptional control....
6.
Hafner A, Boettiger A
Nat Rev Genet
. 2022 Sep;
24(1):53-68.
PMID: 36104547
In animals, the sequences for controlling gene expression do not concentrate just at the transcription start site of genes, but are frequently thousands to millions of base pairs distal to...
7.
Llimos G, Gardeux V, Koch U, Kribelbauer J, Hafner A, Alpern D, et al.
Nat Commun
. 2022 Apr;
13(1):2042.
PMID: 35440565
Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named "variable chromatin modules" (VCMs), providing a conceptual...
8.
Annabi N, Baker M, Boettiger A, Chakraborty D, Chen Y, Corbett K, et al.
Nat Biotechnol
. 2021 Mar;
39(3):281-286.
PMID: 33692517
No abstract available.
9.
Woglar A, Yamaya K, Roelens B, Boettiger A, Kohler S, Villeneuve A
PLoS Biol
. 2020 Aug;
18(8):e3000817.
PMID: 32813728
During meiosis, chromosomes adopt a specialized organization involving assembly of a cohesin-based axis along their lengths, with DNA loops emanating from this axis. We applied novel, quantitative, and widely applicable...
10.
Boettiger A, Murphy S
Trends Genet
. 2020 Feb;
36(4):273-287.
PMID: 32007290
It is now widely appreciated that the spatial organization of the genome is nonrandom, and its complex 3D folding has important consequences for many genome processes. Recent developments in multiplexed,...