Alison MacKinnon
Overview
Explore the profile of Alison MacKinnon including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
14
Citations
651
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0
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Recent Articles
1.
Zetterberg F, MacKinnon A, Brimert T, Gravelle L, Johnsson R, Kahl-Knutson B, et al.
J Med Chem
. 2022 Sep;
65(19):12626-12638.
PMID: 36154172
Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a high affinity (nM) thiodigalactoside GB0139 which...
2.
Lewis P, Campana L, Aleksieva N, Cartwright J, MacKinnon A, ODuibhir E, et al.
J Hepatol
. 2020 Mar;
73(2):349-360.
PMID: 32169610
Background & Aim: Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation,...
3.
Woodward J, MacKinnon A, Keers R
Int J Clin Pharm
. 2019 Jul;
41(5):1332-1340.
PMID: 31321656
Background The involvement of pharmacy technicians in medicines administration has been highlighted as an opportunity to enhance medicines management support for nurses and service users. Currently, there is no published...
4.
Fernandez A, Vermeren M, Humphries D, Subiros-Funosas R, Barth N, Campana L, et al.
ACS Cent Sci
. 2017 Oct;
3(9):995-1005.
PMID: 28979941
Immunomodulatory agents represent one of the most promising strategies for enhancing tissue regeneration without the side effects of traditional drug-based therapies. Tissue repair depends largely on macrophages, making them ideal...
5.
Rajput V, MacKinnon A, Mandal S, Collins P, Blanchard H, Leffler H, et al.
J Med Chem
. 2016 Aug;
59(17):8141-7.
PMID: 27500311
Synthesis of doubly 3-O-coumarylmethyl-substituted thiodigalactosides from bis-3-O-propargyl-thiodigalactoside resulted in highly selective and high affinity galectin-3 inhibitors. Mutant studies, structural analysis, and molecular modeling revealed that the coumaryl substituents stack onto...
6.
Delaine T, Collins P, MacKinnon A, Sharma G, Stegmayr J, Rajput V, et al.
Chembiochem
. 2016 Jun;
17(18):1759-70.
PMID: 27356186
Discovery of glycan-competitive galectin-3-binding compounds that attenuate lung fibrosis in a murine model and that block intracellular galectin-3 accumulation at damaged vesicles, hence revealing galectin-3-glycan interactions involved in fibrosis progression...
7.
Lu W, Bird T, Boulter L, Tsuchiya A, Cole A, Hay T, et al.
Nat Cell Biol
. 2015 Jul;
17(8):971-983.
PMID: 26192438
Hepatocytes and cholangiocytes self-renew following liver injury. Following severe injury hepatocytes are increasingly senescent, but whether hepatic progenitor cells (HPCs) then contribute to liver regeneration is unclear. Here, we describe...
8.
MacKinnon A, Forbes S
Biochim Biophys Acta
. 2013 Feb;
1832(7):955-61.
PMID: 23385196
Bone marrow transplant experiments in mice using labelled donor bone marrow have indicated that following injury bone marrow derived cells can circulate and home to the injured organs. In particular...
9.
Dhaliwal K, Scholefield E, Ferenbach D, Gibbons M, Duffin R, Dorward D, et al.
Am J Respir Crit Care Med
. 2012 Jul;
186(6):514-24.
PMID: 22822022
Rationale: Acute lung injury (ALI) is an important cause of morbidity and mortality, with no currently effective pharmacological therapies. Neutrophils have been specifically implicated in the pathogenesis of ALI, and...
10.
Wang W, Hodkinson P, McLaren F, MacKinnon A, Wallace W, Howie S, et al.
Int J Cancer
. 2012 Apr;
131(6):E928-37.
PMID: 22532287
Small cell lung cancer (SCLC) kills at least one person every 2 hr in the United Kingdom. Some patients do relatively well but most have rapidly progressive disease. There is...