Alisha Aman
Overview
Explore the profile of Alisha Aman including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
124
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Recent Articles
1.
Hayman M, Jones W, Aman A, Ward J, Anderson J, Lyall D, et al.
Diabetes Obes Metab
. 2025 Jan;
27(4):1845-1858.
PMID: 39838854
Aims: Glucagon-like peptide 1 receptor agonists (GLP1RA), used to treat type 2 diabetes and obesity, have been associated with off-target behavioural effects. We systematically assessed genetic variation in the GLP1R...
2.
Aman A, Slob E, Ward J, Sattar N, Strawbridge R
PLoS One
. 2024 Sep;
19(9):e0310396.
PMID: 39325747
PCSK9-inhibitors (PCSK9i) are new drugs recently approved to lower LDL-cholesterol levels. However, due to the lack of long-term clinical data, the potential adverse effects of long-term use are still unknown....
3.
McNeilly S, Thomson C, Gonzalez-Trueba L, Sin Y, Granata A, Hamilton G, et al.
EBioMedicine
. 2024 Aug;
107:105315.
PMID: 39216230
Background: Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain 1/2) occur in genetic and sporadic forms of cerebral small vessel disease (CSVD), a leading cause of stroke,...
4.
McCallum L, Lip S, McConnachie A, Brooksbank K, MacIntyre I, Doney A, et al.
Hypertension
. 2024 Jul;
81(10):2049-2059.
PMID: 39077768
Background: UMOD (uromodulin) has been linked to hypertension through potential activation of Na-K-2Cl cotransporter (NKCC2), a target of loop diuretics. We posited that hypertensive patients carrying the rs13333226-AA genotype would...
5.
Ward J, Lyall L, Cullen B, Strawbridge R, Zhu X, Stanciu I, et al.
Sci Rep
. 2023 Oct;
13(1):17262.
PMID: 37828061
Happiness is a fundamental human affective trait, but its biological basis is not well understood. Using a novel approach, we construct LDpred-inf polygenic scores of a general happiness measure in...
6.
Forsyth L, Aman A, Cullen B, Graham N, Lyall D, Lyall L, et al.
J Affect Disord
. 2023 Jul;
339:943-953.
PMID: 37487843
Background: People with severe mental illness have a higher risk of cardiometabolic disease than the general population. Traditionally attributed to sociodemographic, behavioural factors and medication effects, recent genetic studies have...
7.
Du Toit C, Tran T, Deo N, Aryal S, Lip S, Sykes R, et al.
J Am Heart Assoc
. 2023 Apr;
12(9):e027896.
PMID: 37119074
Background Machine learning (ML) is pervasive in all fields of research, from automating tasks to complex decision-making. However, applications in different specialities are variable and generally limited. Like other conditions,...
8.
Aman A, Slob E, Ward J, Cullen B, Graham N, Lyall D, et al.
PLoS One
. 2022 Dec;
17(12):e0279381.
PMID: 36580462
Prescription of PCSK9-inhibitors has increased in recent years but not much is known about its off-target effects. PCSK9-expression is evident in non-hepatic tissues, notably the brain, and genetic variation in...
9.
Hay R, Cullen B, Graham N, Lyall D, Aman A, Pell J, et al.
Eur J Hum Genet
. 2022 May;
30(12):1380-1390.
PMID: 35501368
The association between severe mental illness (SMI) and cardiovascular and metabolic disease (CMD) is poorly understood. PCSK9 is expressed in systems critical to both SMI and CMD and influences lipid...
10.
Kulyte A, Aman A, Strawbridge R, Arner P, Dahlman I
Diabetes
. 2022 Mar;
71(6):1350-1362.
PMID: 35320353
Interindividual differences in generation of new fat cells determine body fat and type 2 diabetes risk. In the GENetics of Adipocyte Lipolysis (GENiAL) cohort, which consists of participants who have...