Ali H Brivanlou
Overview
Explore the profile of Ali H Brivanlou including associated specialties, affiliations and a list of published articles.
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106
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6458
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Recent Articles
1.
Soman R, Fabiszak M, McPhee M, Schade P, Freiwald W, Brivanlou A
J Assist Reprod Genet
. 2024 Mar;
41(5):1319-1328.
PMID: 38446290
Purpose: The common marmoset (Callithrix jacchus) provides an ideal model to study early development of primates, and an in vivo platform to validate conclusions from in vitro studies of human...
2.
De Santis R, Rice E, Croft G, Yang M, Rosado-Olivieri E, Brivanlou A
Stem Cell Reports
. 2023 Dec;
19(1):41-53.
PMID: 38101401
While studied extensively in model systems, human gastrulation remains obscure. The scarcity of fetal biological material as well as ethical considerations limit our understanding of this process. In vitro attachment...
3.
Laundos T, Li S, Cheang E, De Santis R, Piccolo F, Brivanlou A
Front Cell Dev Biol
. 2023 Sep;
11:1252521.
PMID: 37727506
Huntington's disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene () was identified as the cause. The underlying pathological mechanism, whether loss...
4.
Metzger J, Pereda C, Adhikari A, Haremaki T, Galgoczi S, Siggia E, et al.
Cell Rep Methods
. 2022 Sep;
2(9):100297.
PMID: 36160045
Organoids are carrying the promise of modeling complex disease phenotypes and serving as a powerful basis for unbiased drug screens, potentially offering a more efficient drug-discovery route. However, unsolved technical...
5.
Yoney A, Bai L, Brivanlou A, Siggia E
Development
. 2022 Jul;
149(20).
PMID: 35815787
Embryogenesis is guided by a limited set of signaling pathways dynamically expressed in different places. How a context-dependent signaling response is generated has been a central question of developmental biology,...
6.
Simunovic M, Siggia E, Brivanlou A
Cell Stem Cell
. 2022 Jun;
29(6):962-972.e4.
PMID: 35659878
Our knowledge of the molecular mechanisms surrounding human embryo implantation and gastrulation is lacking, largely due to technical and ethical limitations of experimenting with human embryos. Alternatives to human embryos...
7.
Piccolo F, Kastan N, Haremaki T, Tian Q, Laundos T, De Santis R, et al.
Elife
. 2022 Apr;
11.
PMID: 35451959
The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coactivator Yes-associated protein 1 (YAP). Hippo-YAP...
8.
De Santis R, Etoc F, Rosado-Olivieri E, Brivanlou A
Nat Commun
. 2021 Nov;
12(1):6768.
PMID: 34799555
Organizing centers secrete morphogens that specify the emergence of germ layers and the establishment of the body's axes during embryogenesis. While traditional experimental embryology tools have been instrumental in dissecting...
9.
Valet M, Siggia E, Brivanlou A
Nat Rev Mol Cell Biol
. 2021 Nov;
23(3):169-184.
PMID: 34754086
Embryonic cells grow in environments that provide a plethora of physical cues, including mechanical forces that shape the development of the entire embryo. Despite their prevalence, the role of these...
10.
Galgoczi S, Ruzo A, Markopoulos C, Yoney A, Phan-Everson T, Li S, et al.
Development
. 2021 Oct;
148(19).
PMID: 34608934
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the huntingtin gene (HTT). Although HD has been shown to have a developmental...