Ali Al-Hakim
Overview
Explore the profile of Ali Al-Hakim including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
16
Citations
673
Followers
0
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Recent Articles
1.
Al-Hakim A
Clin Appl Thromb Hemost
. 2021 Dec;
27:10760296211052293.
PMID: 34894779
Heparin is one of the most widely used drugs in the world. It has been described as a lifesaving drug due to its roles in treating many serious diseases and...
2.
Szajek A, Chess E, Johansen K, Gratzl G, Gray E, Keire D, et al.
Nat Biotechnol
. 2016 Jun;
34(6):625-30.
PMID: 27281424
The contamination of the widely used lifesaving anticoagulant drug heparin in 2007 has drawn renewed attention to the challenges that are associated with the characterization, quality control and standardization of...
3.
De Claro R, McGinn K, Verdun N, Lee S, Chiu H, Saber H, et al.
Clin Cancer Res
. 2015 Aug;
21(16):3586-90.
PMID: 26275952
On November 13, 2013, the FDA granted accelerated approval to ibrutinib (IMBRUVICA capsules; Pharmacyclics, Inc.) for the treatment of patients with mantle cell lymphoma (MCL) who have received at least...
4.
Amiri-Kordestani L, Blumenthal G, Xu Q, Zhang L, Tang S, Ha L, et al.
Clin Cancer Res
. 2014 Jun;
20(17):4436-41.
PMID: 24879797
On February 22, 2013, the FDA licensed ado-trastuzumab emtansine (Kadcyla; Genentech, Inc.) for use as a single agent for the treatment of patients with human epidermal growth factor receptor 2...
5.
Kluetz P, Pierce W, Maher V, Zhang H, Tang S, Song P, et al.
Clin Cancer Res
. 2013 Nov;
20(1):9-14.
PMID: 24190979
On May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium Ra 223 dichloride (Ra-223; Xofigo injection; Bayer HealthCare Pharmaceuticals Inc.) for the treatment of patients with castration-resistant...
6.
Ye H, Toby T, Sommers C, Ghasriani H, Trehy M, Ye W, et al.
J Pharm Biomed Anal
. 2013 Aug;
85:99-107.
PMID: 23917037
During the 2007-2008 heparin crisis it was found that the United States Pharmacopeia (USP) testing monograph for heparin sodium or low molecular weight heparins did not detect the presence of...
7.
Wang B, Buhse L, Al-Hakim A, Boyne Ii M, Keire D
J Pharm Biomed Anal
. 2012 May;
67-68:42-50.
PMID: 22633605
Previously, the FDA validated a method to assess the structure and composition of heparin products by separating and quantifying disaccharide level digests by reverse-phase-ion-pairing liquid chromatography (RPIP-HPLC) coupled to a...
8.
Sommers C, Ye H, Kolinski R, Nasr M, Buhse L, Al-Hakim A, et al.
Anal Bioanal Chem
. 2011 Sep;
401(8):2445-54.
PMID: 21901459
We evaluated polyacrylamide gel electrophoresis (PAGE) and size exclusion chromatography coupled with multi-angle laser light scattering (SEC-MALLS) approaches to determine weight-average molecular weight (M(w)) and polydispersity (PD) of heparins. A...
9.
Zang Q, Keire D, Buhse L, Wood R, Mital D, Haque S, et al.
Anal Bioanal Chem
. 2011 Jun;
401(3):939-55.
PMID: 21678118
Chemometric analysis of a set of one-dimensional (1D) (1)H nuclear magnetic resonance (NMR) spectral data for heparin sodium active pharmaceutical ingredient (API) samples was employed to distinguish USP-grade heparin samples...
10.
Zang Q, Keire D, Wood R, Buhse L, Moore C, Nasr M, et al.
J Pharm Biomed Anal
. 2011 Jan;
54(5):1020-9.
PMID: 21215547
Heparin is a naturally produced, heterogeneous compound consisting of variably sulfated and acetylated repeating disaccharide units. The structural complexity of heparin complicates efforts to assess the purity of the compound,...