Alfred M Engel
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Explore the profile of Alfred M Engel including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
262
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Recent Articles
1.
Friligou I, Gassner J, Knoblauch D, Kagerer G, Popp F, Voit S, et al.
Glycobiology
. 2021 Feb;
31(7):762-771.
PMID: 33554253
Recombinant immunoglobulins (rIgGs) have become increasingly important as therapeutic agents and diagnostic tools in recent years. Genetic engineering allows the introduction of non-natural features such as the Sortase motif for...
2.
Kunzel C, Abdolzade-Bavil A, Engel A, Pleitner M, Schick E, Stubenrauch K
Bioanalysis
. 2021 Feb;
13(4):253-263.
PMID: 33544012
Development and qualification of an easy-to-use ELISA for detection of IgM anti-drug antibodies (ADA) and its use in a clinical Phase I trial. During the assay development two positive control...
3.
Kiszel P, Fiesel S, Voit S, Waechtler B, Meier T, Oelschlaegel T, et al.
Biotechnol Prog
. 2019 Feb;
35(3):e2786.
PMID: 30758913
Transient gene expression (TGE) in HEK293 cells was optimized by Vink et al. by co-expression of human cell cycle inhibitors p21 /p27 and Simian virus 40 large T antigen (SVLT)....
4.
van Dieck J, Schmid V, Heindl D, Dziadek S, Schraeml M, Gerg M, et al.
Chem Biol
. 2014 Feb;
21(3):357-68.
PMID: 24529991
Investigation of protein-protein interactions (PPIs) and protein phosphorylation in clinical tissue samples can offer valuable information about the activation status and function of proteins involved in disease progression. However, existing...
5.
Kuhn B, Benz J, Greif M, Engel A, Sobek H, Rudolph M
Acta Crystallogr D Biol Crystallogr
. 2013 Sep;
69(Pt 9):1826-38.
PMID: 23999306
Human β-galactoside α-2,6-sialyltransferase I (ST6Gal-I) establishes the final glycosylation pattern of many glycoproteins by transferring a sialyl moiety to a terminal galactose. Complete sialylation of therapeutic immunoglobulins is essential for...
6.
Kaufman T, McLinden J, Xiang J, Engel A, Stapleton J
AIDS
. 2007 Apr;
21(8):1045-8.
PMID: 17457101
The addition of GB virus C (GBV-C) E2 protein to cells inhibits HIV replication in vitro, presumably triggered by interactions with a specific cellular receptor. Indirect evidence suggests that CD81...
7.
Jung S, Eichenmuller M, Donhauser N, Neipel F, Engel A, Hess G, et al.
AIDS
. 2007 Feb;
21(5):645-7.
PMID: 17314528
Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein...
8.
McLinden J, Kaufman T, Xiang J, Chang Q, Klinzman D, Engel A, et al.
J Virol
. 2006 Oct;
80(24):12131-40.
PMID: 17035329
GB virus type C (GBV-C) is a human flavivirus that may cause persistent infection, although most infected individuals clear viremia and develop antibodies to the envelope glycoprotein E2. To study...
9.
Roessler M, Rollinger W, Mantovani-Endl L, Hagmann M, Palme S, Berndt P, et al.
Mol Cell Proteomics
. 2006 Aug;
5(11):2092-101.
PMID: 16893879
The purpose of this study was to identify and validate novel serological protein biomarkers of human colorectal cancer (CRC). Proteins from matched CRC and adjacent normal tissue samples were resolved...
10.
Roessler M, Rollinger W, Palme S, Hagmann M, Berndt P, Engel A, et al.
Clin Cancer Res
. 2005 Sep;
11(18):6550-7.
PMID: 16166432
Purpose: The goal of this study was to identify and validate novel serum markers of human colorectal cancer as potential candidates for noninvasive detection of early colorectal neoplasm. Experimental Design:...