Alfonso R Sanchez-Paulete
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Explore the profile of Alfonso R Sanchez-Paulete including associated specialties, affiliations and a list of published articles.
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18
Citations
1042
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Recent Articles
1.
Sanchez-Paulete A, Mateus-Tique J, Mollaoglu G, Nielsen S, Marks A, Lakshmi A, et al.
Cancer Immunol Res
. 2022 Sep;
10(11):1354-1369.
PMID: 36095236
Tumor-associated macrophages (TAM) are one of the most abundant cell types in many solid tumors and typically exert protumor effects. This has led to an interest in macrophage-depleting agents for...
2.
Cueto F, Del Fresno C, Brandi P, Combes A, Hernandez-Garcia E, Sanchez-Paulete A, et al.
J Immunother Cancer
. 2021 May;
9(5).
PMID: 33980589
Background: Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is...
3.
Minute L, Teijeira A, Sanchez-Paulete A, Ochoa M, Alvarez M, Otano I, et al.
J Immunother Cancer
. 2020 Mar;
8(1).
PMID: 32217765
Background: The immune response to cancer is often conceptualized with the cancer immunity cycle. An essential step in this interpretation is that antigens released by dying tumors are presented by...
4.
Etxeberria I, Bolanos E, Quetglas J, Gros A, Villanueva A, Palomero J, et al.
Cancer Cell
. 2019 Nov;
36(6):613-629.e7.
PMID: 31761658
Retroviral gene transfer of interleukin-12 (IL-12) into T cells markedly enhances antitumor efficacy upon adoptive transfer but has clinically shown unacceptable severe side effects. To overcome the toxicity, we engineered...
5.
Aznar M, Molina C, Teijeira A, Rodriguez I, Azpilikueta A, Garasa S, et al.
EMBO Mol Med
. 2019 Nov;
12(1):e10375.
PMID: 31746149
Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild-type pathogen. 17D replicates and kills...
6.
Ballesteros-Briones M, Martisova E, Casales E, Silva-Pilipich N, Bunuales M, Galindo J, et al.
Mol Ther
. 2019 Sep;
27(11):1892-1905.
PMID: 31563534
Immune checkpoint blockade has shown anti-cancer efficacy, but requires systemic administration of monoclonal antibodies (mAbs), often leading to adverse effects. To avoid toxicity, mAbs could be expressed locally in tumors....
7.
Sanchez-Paulete A, Teijeira A, Quetglas J, Rodriguez-Ruiz M, Sanchez-Arraez A, Labiano S, et al.
Cancer Res
. 2018 Oct;
78(23):6643-6654.
PMID: 30297531
: Multiple lines of evidence indicate a critical role of antigen cross-presentation by conventional BATF3-dependent type 1 classical dendritic cells (cDC1) in CD8-mediated antitumor immunity. Flt3L and XCL1, respectively, constitute...
8.
Teijeira A, Labiano S, Garasa S, Etxeberria I, Santamaria E, Rouzaut A, et al.
Cancer Immunol Res
. 2018 Apr;
6(7):798-811.
PMID: 29678874
T and NK lymphocytes express CD137 (4-1BB), a costimulatory receptor of the TNFR family whose function is exploitable for cancer immunotherapy. Mitochondria regulate the function and survival of T lymphocytes....
9.
Aznar M, Labiano S, Diaz-Lagares A, Molina C, Garasa S, Azpilikueta A, et al.
Cancer Immunol Res
. 2017 Nov;
6(1):69-78.
PMID: 29133290
CD137 (4-1BB) costimulation imprints long-term changes that instruct the ultimate behavior of T cells that have previously experienced CD137 ligation. Epigenetic changes could provide a suitable mechanism for these long-term...
10.
Labiano S, Melendez-Rodriguez F, Palazon A, Teijeira A, Garasa S, Etxeberria I, et al.
Oncoimmunology
. 2017 May;
6(4):e1283468.
PMID: 28507790
CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognate antigen. We observed intense expression of CD69 on tumor-infiltrating T-lymphocytes that reside in the...