Alexei Korennykh
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Explore the profile of Alexei Korennykh including associated specialties, affiliations and a list of published articles.
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20
Citations
854
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Recent Articles
1.
Solorio-Kirpichyan K, Fan X, Golovenko D, Korostelev A, Yan N, Korennykh A
PNAS Nexus
. 2024 Dec;
3(12):pgae528.
PMID: 39618511
GCN2 is a conserved receptor kinase activating the integrated stress response (ISR) in eukaryotic cells. The ISR kinases detect accumulation of stress molecules and reprogram translation from basal tasks to...
2.
Solorio-Kirpichyan K, Fan X, Golovenko D, Korostelev A, Yan N, Korennykh A
bioRxiv
. 2024 May;
PMID: 38712127
Significance Statement: Regulation of protein synthesis (translation) is a central mechanism by which eukaryotic cells adapt to stressful conditions. In starving cells, this translational adaptation is achieved via the receptor...
3.
Prangley E, Korennykh A
Crit Rev Biochem Mol Biol
. 2023 Mar;
57(5-6):477-491.
PMID: 36939319
Mammalian cells are exquisitely sensitive to the presence of double-stranded RNA (dsRNA), a molecule that they interpret as a signal of viral presence requiring immediate attention. Upon sensing dsRNA cells...
4.
Du J, Estrella M, Solorio-Kirpichyan K, Jeffrey P, Korennykh A
Proc Natl Acad Sci U S A
. 2022 Jun;
119(26):e2200923119.
PMID: 35733246
All kingdoms of life produce essential nicotinamide dinucleotide NADP(H) using NAD kinases (NADKs). A panel of published NADK structures from bacteria, eukaryotic cytosol, and yeast mitochondria revealed similar tetrameric enzymes....
5.
Balaich J, Estrella M, Wu G, Jeffrey P, Biswas A, Zhao L, et al.
Nature
. 2021 Nov;
600(7887):110-115.
PMID: 34819672
The human microbiome encodes a large repertoire of biochemical enzymes and pathways, most of which remain uncharacterized. Here, using a metagenomics-based search strategy, we discovered that bacterial members of the...
6.
Chitrakar A, Solorio-Kirpichyan K, Prangley E, Rath S, Du J, Korennykh A
Proc Natl Acad Sci U S A
. 2021 Nov;
118(46).
PMID: 34772806
Double-stranded RNA (dsRNA), a hallmark viral material that activates antiviral interferon (IFN) responses, can appear in human cells also in the absence of viruses. We identify phosphorothioate DNAs (PS DNAs)...
7.
Rath S, Prangley E, Donovan J, Demarest K, Wingreen N, Meir Y, et al.
Mol Cell
. 2019 Sep;
75(6):1218-1228.e6.
PMID: 31494033
Viral and endogenous double-stranded RNA (dsRNA) is a potent trigger for programmed RNA degradation by the 2-5A/RNase L complex in cells of all mammals. This 2-5A-mediated decay (2-5AMD) is a...
8.
Estrella M, Du J, Chen L, Rath S, Prangley E, Chitrakar A, et al.
Nat Commun
. 2019 Jun;
10(1):2367.
PMID: 31147539
Nocturnin (NOCT) is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has been proposed that NOCT deadenylates and regulates metabolic enzyme mRNAs. However, in...
9.
Chitrakar A, Rath S, Donovan J, Demarest K, Li Y, Sridhar R, et al.
Proc Natl Acad Sci U S A
. 2019 Jan;
116(6):2103-2111.
PMID: 30655338
Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material. In response, they release interferons (IFNs) and activate a ubiquitously expressed pseudokinase/endoribonuclease RNase L. RNase L executes regulated...
10.
Estrella M, Du J, Korennykh A
Sci Rep
. 2018 Nov;
8(1):16294.
PMID: 30389976
Nocturnin (NOCT) helps the circadian clock to adjust metabolism according to day and night activity. NOCT is upregulated in early evening and it has been proposed that NOCT serves as...