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Alexandre Pertzev

Explore the profile of Alexandre Pertzev including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 148
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Recent Articles
1.
Makino C, Duda T, Pertzev A, Isayama T, Geva P, Sandberg M, et al.
eNeuro . 2019 Feb; 6(1). PMID: 30783616
The membrane guanylate cyclase, ROS-GC, that synthesizes cyclic GMP for use as a second messenger for visual transduction in retinal rods and cones, is stimulated by bicarbonate. Bicarbonate acts directly...
2.
Duda T, Pertzev A, Ravichandran S, Sharma R
Front Mol Neurosci . 2018 Dec; 11:430. PMID: 30546296
Prototype member of the membrane guanylate cyclase family, ANF-RGC (Atrial Natriuretic Factor Receptor Guanylate Cyclase), is the physiological signal transducer of two most hypotensive hormones ANF and BNP, and of...
3.
Makino C, Duda T, Pertzev A, Sharma R
Methods Mol Biol . 2018 Mar; 1753:129-158. PMID: 29564786
Our ability to see is based on the activity of retinal rod and cone photoreceptors. Rods function when there is very little light, while cones operate at higher light levels....
4.
Ravichandran S, Duda T, Pertzev A, Sharma R
Front Mol Neurosci . 2017 Jun; 10:173. PMID: 28638321
Membrane guanylate cyclase (MGC) is a ubiquitous multi-switching cyclic GMP generating signaling machine linked with countless physiological processes. In mammals it is encoded by seven distinct homologous genes. It is...
5.
Duda T, Pertzev A, Makino C, Sharma R
Front Mol Neurosci . 2016 Feb; 9:5. PMID: 26858600
Photoreceptor ROS-GC1, a prototype subfamily member of the membrane guanylate cyclase family, is a central component of phototransduction. It is a single transmembrane-spanning protein, composed of modular blocks. In rods,...
6.
Duda T, Pertzev A, Sharma R
Front Mol Neurosci . 2014 Mar; 7:17. PMID: 24672425
Atrial natriuretic factor receptor guanylate cyclase (ANF-RGC), was the first discovered member of the mammalian membrane guanylate cyclase family. The hallmark feature of the family is that a single protein...
7.
Duda T, Pertzev A, Sharma R
Biochemistry . 2013 Mar; 52(13):2337-47. PMID: 23464624
ANF-RGC is the prototype membrane guanylate cyclase, both the receptor and the signal transducer of the hormones ANF and BNP. After binding them at the extracellular domain, it, at its...
8.
Duda T, Pertzev A, Sharma R
Biochemistry . 2012 Oct; 51(46):9394-405. PMID: 23088492
ANF-RGC is the prototype receptor membrane guanylate cyclase that is both the receptor and the signal transducer of the most hypotensive hormones, ANF and BNP. It is a single-transmembrane protein....
9.
Duda T, Pertzev A, Sharma R
Biochemistry . 2012 May; 51(23):4650-7. PMID: 22642846
Photoreceptor ROS-GC1 (rod outer segment membrane guanylate cyclase) is a vital component of phototransduction. It is a bimodal Ca(2+) signal transduction switch, operating between 20 and ∼1000 nM. Modulated by...
10.
Duda T, Pertzev A, Koch K, Sharma R
Front Mol Neurosci . 2012 Apr; 5:44. PMID: 22509151
THE MEMBRANE GUANYLATE CYCLASE FAMILY HAS BEEN BRANCHED INTO THREE SUBFAMILIES: natriuretic peptide hormone surface receptors, Ca(2+)-modulated neuronal ROS-GC, and Ca(2+)-modulated odorant surface receptor ONE-GC. The first subfamily is solely...