Alexandre Lewalle
Overview
Explore the profile of Alexandre Lewalle including associated specialties, affiliations and a list of published articles.
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12
Citations
262
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Recent Articles
1.
Lewalle A, Milburn G, Campbell K, Niederer S
Biophys J
. 2024 May;
123(18):2996-3009.
PMID: 38807364
The length-dependent activation (LDA) of maximum force and calcium sensitivity are established features of cardiac muscle contraction but the dominant underlying mechanisms remain to be fully clarified. Alongside the well-documented...
2.
Rodero C, Baptiste T, Barrows R, Lewalle A, Niederer S, Strocchi M
Front Phys
. 2024 Mar;
11:1306210.
PMID: 38500690
Cardiac mechanics models are developed to represent a high level of detail, including refined anatomies, accurate cell mechanics models, and platforms to link microscale physiology to whole-organ function. However, cardiac...
3.
Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett D, et al.
Circ Res
. 2020 Feb;
126(7):889-906.
PMID: 32070187
Rationale: Hypokalemia occurs in up to 20% of hospitalized patients and is associated with increased incidence of ventricular and atrial fibrillation. It is unclear whether these differing types of arrhythmia...
4.
Lewalle A, Land S, Merken J, Raafs A, Sepulveda P, Heymans S, et al.
Biophys J
. 2019 Aug;
117(12):2337-2348.
PMID: 31447110
Late-onset heart failure (HF) is a known side effect of doxorubicin chemotherapy. Typically, patients are diagnosed when already at an irreversible stage of HF, which allows few or no treatment...
5.
Lewalle A, Land S, Carruth E, Frank L, Lamata P, Omens J, et al.
Front Physiol
. 2018 Mar;
9:37.
PMID: 29527171
The cardiac system compensates for variations in physiological and pathophysiological conditions through a dynamic remodeling at the organ, tissue, and intracellular levels in order to maintain function. However, on longer...
6.
Lewalle A, Fritzsche M, Wilson K, Thorogate R, Duke T, Charras G
Interface Focus
. 2014 Dec;
4(6):20140006.
PMID: 25485077
The integration of protein function studied in vitro in a dynamic system like the cell lamellipodium remains a significant challenge. One reason is the apparent contradictory effect that perturbations of...
7.
Lewalle A, Niederer S, Smith N
J Physiol
. 2014 Nov;
592(24):5355-71.
PMID: 25362154
The Na(+)/K(+) ATPase (NKA) plays a critical role in maintaining ionic homeostasis and dynamic function in cardiac myocytes, within both the in vivo cell and in silico models. Physiological conditions...
8.
Wilson K, Lewalle A, Fritzsche M, Thorogate R, Duke T, Charras G
Nat Commun
. 2013 Dec;
4:2896.
PMID: 24305616
While the molecular and biophysical mechanisms underlying cell protrusion on two-dimensional substrates are well understood, our knowledge of the actin structures driving protrusion in three-dimensional environments is poor, despite relevance...
9.
Fritzsche M, Lewalle A, Duke T, Kruse K, Charras G
Mol Biol Cell
. 2013 Jan;
24(6):757-67.
PMID: 23345594
The cell cortex is a thin network of actin, myosin motors, and associated proteins that underlies the plasma membrane in most eukaryotic cells. It enables cells to resist extracellular stresses,...
10.
Lewalle A, Parker K
J Biomech Eng
. 2010 Dec;
133(1):011007.
PMID: 21186897
The elastic properties of the cell membrane play a crucial role in determining the equilibrium shape of the cell, as well as its response to the external forces it experiences...