Alexandre F Aissa
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Explore the profile of Alexandre F Aissa including associated specialties, affiliations and a list of published articles.
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8
Citations
168
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Recent Articles
1.
Principe D, Pasquinelli M, Nguyen R, Munshi H, Hulbert A, Aissa A, et al.
Cancer Res Commun
. 2024 Aug;
4(8):2282-2294.
PMID: 39113608
Significance: In patients with lung cancer, we demonstrate that KRAS mutations increase tumor immunogenicity; however, KRAS/STK11 co-mutated patients display an immune-excluded phenotype. KRAS/STK11 co-mutated patients also demonstrated significant downregulation of...
2.
Principe D, Aissa A, Kumar S, Pham T, Underwood P, Nair R, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(18):e2200143119.
PMID: 35476525
There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC). While palliative chemotherapy offers a survival benefit to most patients, nearly all will eventually progress on treatment and long-term...
3.
Blaha C, Ramakrishnan G, Jeon S, Nogueira V, Rho H, Kang S, et al.
Nat Commun
. 2022 Feb;
13(1):899.
PMID: 35173161
Hexokinase 2 (HK2), which catalyzes the first committed step in glucose metabolism, is induced in cancer cells. HK2's role in tumorigenesis has been attributed to its glucose kinase activity. Here,...
4.
De Grandis R, Oliveira K, Guedes A, Dos Santos P, Aissa A, Batista A, et al.
Front Oncol
. 2021 Jul;
11:682968.
PMID: 34249731
Lapachol is a well-studied natural product that has been receiving great interest due to its anticancer properties that target oxidative stress. In the present work, two novel lapachol-containing ruthenium(II) complexes...
5.
Aissa A, Islam A, Ariss M, Go C, Rader A, Conrardy R, et al.
Nat Commun
. 2021 Mar;
12(1):1628.
PMID: 33712615
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, the duration of clinical...
6.
Costa T, Amstalden M, Ribeiro D, Menaldo D, Sartim M, Aissa A, et al.
Toxicology
. 2018 May;
404-405:42-48.
PMID: 29738841
Snake venom L-amino acid oxidases (SV-LAAOs) are enzymes of great interest in research due to their many biological effects with therapeutic potential. CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma...
7.
Chequer F, Venancio V, Almeida M, Aissa A, Bianchi M, Antunes L
Toxicol Ind Health
. 2017 Sep;
33(10):765-774.
PMID: 28893156
Erythrosine B (ErB) is a cherry pink food colorant and is widely used in foods, drugs, and cosmetics. Quinoline yellow (QY) is a chinophthalon derivative used in cosmetic compositions for...
8.
Costa T, Menaldo D, Zoccal K, Burin S, Aissa A, de Castro F, et al.
Sci Rep
. 2017 Feb;
7:42673.
PMID: 28205610
L-amino acid oxidases from snake venoms have been described to possess various biological functions. In this study, we investigated the inflammatory responses induced in vivo and in vitro by CR-LAAO,...