Alexandra Wigger
Overview
Explore the profile of Alexandra Wigger including associated specialties, affiliations and a list of published articles.
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16
Citations
508
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Recent Articles
1.
Jochum T, Boettger M, Wigger A, Beiderbeck D, Neumann I, Landgraf R, et al.
Behav Brain Res
. 2007 Jun;
183(1):18-24.
PMID: 17599477
Complex interactions between pain perception, anxiety and depressive symptoms have repeatedly been described. However, pathophysiological or biochemical mechanisms underlying the alterations of pain perception in patients suffering from anxiety or...
2.
Muigg P, Hoelzl U, Palfrader K, Neumann I, Wigger A, Landgraf R, et al.
Biol Psychiatry
. 2007 Jan;
61(6):782-96.
PMID: 17224133
Background: The enhanced depression-like behavior in the forced swim test displayed by rats selectively bred for high anxiety-related behavior (HAB) as compared with their low anxiety counterparts (LAB) is abolished...
3.
Salchner P, Sartori S, Sinner C, Wigger A, Frank E, Landgraf R, et al.
Neuropharmacology
. 2006 Apr;
50(8):1048-58.
PMID: 16620881
We reported recently that two rat lines bred for either high (HAB) or low (LAB) anxiety-related behavior display differential Fos expression in restricted parts of the fear/anxiety circuitry when exposed...
4.
Frank E, Salchner P, Aldag J, Salome N, Singewald N, Landgraf R, et al.
Behav Neurosci
. 2006 Feb;
120(1):60-71.
PMID: 16492117
Genetic background may influence an individual's susceptibility to, and subsequent coping strategy for, an acute stressor. When exposed to social defeat (SD), rats bred for high (HAB) or low (LAB)...
5.
Kalisch R, Schubert M, Jacob W, Kessler M, Hemauer R, Wigger A, et al.
Neuropsychopharmacology
. 2005 Sep;
31(5):925-32.
PMID: 16192979
In depressed patients as well as healthy controls, a positive relationship between hippocampal volume and trait anxiety has been reported. This study sought to explore the possible inter-relation between hippocampal...
6.
Murgatroyd C, Wigger A, Frank E, Singewald N, Bunck M, Holsboer F, et al.
J Neurosci
. 2004 Sep;
24(35):7762-70.
PMID: 15342744
Two inbred rat lines have been developed that show either high (HAB) or low (LAB) anxiety-related behavior. The behavioral phenotype correlates with arginine vasopressin (AVP) expression at the level of...
7.
Kalisch R, Salome N, Platzer S, Wigger A, Czisch M, Sommer W, et al.
Neuroimage
. 2004 Aug;
23(1):382-91.
PMID: 15325386
The neural basis of trait anxiety is poorly understood. In genetically selected hyperanxious (high anxiety-related behavior; HAB) rats, diazepam induces a stronger anxiolytic response than in hypoanxious (low anxiety-related behavior;...
8.
Salome N, Salchner P, Viltart O, Sequeira H, Wigger A, Landgraf R, et al.
Biol Psychiatry
. 2004 Mar;
55(7):715-23.
PMID: 15039000
Background: Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety. Methods: We used Fos expression...
9.
Wigger A, Sanchez M, Mathys K, Ebner K, Frank E, Liu D, et al.
Neuropsychopharmacology
. 2003 Aug;
29(1):1-14.
PMID: 12942143
To model aspects of trait anxiety/depression, Wistar rats were bred for extremes in either hyper (HAB)- or hypo(LAB)-anxiety as measured on the elevated plus-maze and in a variety of additional...
10.
Landgraf R, Frank E, Aldag J, Neumann I, Sharer C, Ren X, et al.
Eur J Neurosci
. 2003 Jul;
18(2):403-11.
PMID: 12887422
This study explores the effects of enhancing vasopressin V1a receptor expression in the septum using viral vector-mediated gene transfer on social discrimination and social interactions. Bilateral infusion of an adeno-associated...