Alexandra F Freeman
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Explore the profile of Alexandra F Freeman including associated specialties, affiliations and a list of published articles.
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8731
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Recent Articles
11.
Shanmugasundaram K, Napier S, Dimitrova D, Stokes A, Wilder J, Chai A, et al.
Bone Marrow Transplant
. 2024 Aug;
59(11):1513-1524.
PMID: 39134710
The therapeutic efficacy of donor lymphocyte infusions (DLIs) given after allogeneic hematopoietic cell transplantation (HCT) is limited by risk of graft-versus-host disease (GVHD). Post-transplantation cyclophosphamide (PTCy) effectively prevents severe GVHD,...
12.
Sparks R, Rachmaninoff N, Lau W, Hirsch D, Bansal N, Martins A, et al.
Nat Med
. 2024 Jul;
30(9):2461-2472.
PMID: 38961223
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some immune diseases and the concept of immunologic resilience...
13.
Ferre E, Nichols-Vinueza D, Rosen L, Burbelo P, Fennelly K, Pechacek J, et al.
J Clin Immunol
. 2024 Jul;
44(7):156.
PMID: 38954150
Background: Thymoma presents with several autoimmune manifestations and is associated with secondary autoimmune regulator (AIRE) deficiency. Pneumonitis has recently been described as an autoimmune manifestation associated with thymoma presenting with...
14.
Lindell R, Sayed S, Campos J, Knight M, Mauracher A, Hay C, et al.
medRxiv
. 2024 Jul;
PMID: 38946991
Sepsis is the leading cause of death of hospitalized children worldwide. Despite the established link between immune dysregulation and mortality in pediatric sepsis, it remains unclear which host immune factors...
15.
James A, Abdalgani M, Khoury P, Freeman A, Milner J
J Allergy Clin Immunol
. 2024 May;
154(2):245-254.
PMID: 38761995
Monogenic lesions in pathways critical for effector functions responsible for immune surveillance, protection against autoinflammation, and appropriate responses to allergens and microorganisms underlie the pathophysiology of inborn errors of immunity...
16.
Kucera J, Buhaya M, Sartain N, Olivier K, Freeman A, Hoang C
AME Case Rep
. 2024 May;
8:43.
PMID: 38711888
Background: Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare genetic syndrome that alters typical post-operative wound healing. AD-HIES patients are prone to develop persistent air leaks (PALs) due to bronchopleural...
17.
Cheng A, Kashyap A, Salvator H, Rosen L, Colby D, Ardeshir-Larijani F, et al.
N Engl J Med
. 2024 Mar;
390(12):1105-1117.
PMID: 38507753
Background: Autoantibodies against interleukin-12 (anti-interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with subunits p40 and p35) shares a...
18.
Gopalakrishna H, Asif B, Rai A, Conjeevaram H, Mironova M, Kleiner D, et al.
Case Rep Gastroenterol
. 2024 Feb;
18(1):49-57.
PMID: 38304571
Introduction: Prolidase deficiency is a rare autosomal recessive disorder caused by variants in the gene. Patients usually have multi-organ involvement and a wide range of clinical features including recurrent skin...
19.
Mohsin N, Hunt D, Yan J, Jabbour A, Nghiem P, Choi J, et al.
JAMA Dermatol
. 2024 Jan;
160(2):172-178.
PMID: 38170500
Importance: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer. Of the patients who develop MCC annually, only 4% are younger than 50 years. Objective: To identify genetic...
20.
Delmonte O, Oguz C, Dobbs K, Myint-Hpu K, Palterer B, Abers M, et al.
J Allergy Clin Immunol
. 2023 Dec;
153(6):1655-1667.
PMID: 38154666
Background: Functional T-cell responses are essential for virus clearance and long-term protection after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, whereas certain clinical factors, such as older age and...