Alexander Y Misharin
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Explore the profile of Alexander Y Misharin including associated specialties, affiliations and a list of published articles.
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11
Citations
25
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Recent Articles
1.
Latysheva A, Zolottsev V, Veselovsky A, Scherbakov K, Morozevich G, Zhdanov D, et al.
J Steroid Biochem Mol Biol
. 2023 Mar;
230:106280.
PMID: 36870373
Steroid derivatives modified with nitrogen containing heterocycles are known to inhibit activity of steroidogenic enzymes, decrease proliferation of cancer cells and attract attention as promising anticancer agents. Specifically, 2'-(3β-hydroxyandrosta-5,16-dien-17-yl)-4',5'-dihydro-1',3'-oxazole 1a...
2.
Korolchuk A, Zolottsev V, Misharin A
Top Curr Chem (Cham)
. 2023 Feb;
381(2):10.
PMID: 36826755
Photodynamic therapy is a minimally invasive treatment of tumors using photosensitizers, light, and reactive oxygen species, which can destroy cellular structures. With the development of photodynamic therapy, significant efforts have...
3.
Khan I, Karshieva S, Sokolova D, Spirina T, Zolottsev V, Latysheva A, et al.
Arch Pharm (Weinheim)
. 2021 Oct;
355(1):e2100316.
PMID: 34668210
The aim of this study was to explore the mechanisms of action of alsevirone in prostate cancer (PC) in vitro and in vivo: CYP17A1 inhibition, cytotoxic, apoptotic, and antitumor effects...
4.
Zolottsev V, Latysheva A, Pokrovsky V, Khan I, Misharin A
Eur J Med Chem
. 2020 Dec;
210:113089.
PMID: 33321260
The conjugation of biologically active molecules is a powerful tool for drug discovery used to target a variety of multifunctional diseases including cancer. Conjugated drugs can provide combination therapies in...
5.
Latysheva A, Zolottsev V, Veselovsky A, Scherbakov K, Morozevich G, Pokrovsky V, et al.
Steroids
. 2019 Nov;
153:108534.
PMID: 31678134
Seven new oxazoline, benzoxazole and benzimidazole derivatives were synthesized from 3β-acetoxyandrosta-5,16-dien-17-carboxylic, 3β-acetoxyandrost-5-en-17β-carboxylic and 3β-acetoxypregn-5-en-21-oic acids. Docking to active site of human 17α-hydroxylase/17,20-lyase revealed that all oxazolines, as well as benzoxazoles...
6.
Dalidovich T, Hurski A, Morozevich G, Latysheva A, Sushko T, Strushkevich N, et al.
Steroids
. 2018 Aug;
147:10-18.
PMID: 30149075
A number of isoxazole, 1,2,3-triazole, tetrazole, and 1,2,4-oxadiazole derivatives of [17(20)E]-21-norpregnene comprising 3β-hydroxy-5-ene and 3-oxo-4-ene fragments were prepared. Among the key steps for the synthesis of isoxazoles, 1,2,3-triazoles, and tetrazoles...
7.
Zolottsev V, Ponomarev G, Taratynova M, Morozevich G, Novikov R, Timofeev V, et al.
Steroids
. 2018 Jul;
138:82-90.
PMID: 30033342
Conjugates of 17α-substituted testosterone (1 and 2) and 17β-substituted epitestosterone (3 and 4) with pyropheophorbide a were synthesized. The scheme consisted of synthesis of 17α-hydroxy-3-oxopregn-4-en-21-oic and 17β-hydroxy-3-oxopregn-4-en-21-oic acids, and their...
8.
Zolottsev V, Tkachev Y, Latysheva A, Kostin V, Novikov R, Timofeev V, et al.
Steroids
. 2018 Jun;
136:93.
PMID: 29880207
No abstract available.
9.
Zolottsev V, Tkachev Y, Latysheva A, Kostin V, Novikov R, Timofeev V, et al.
Steroids
. 2017 Nov;
129:24-34.
PMID: 29183745
Four new 4,5-dihydro-1,3-oxazole, and four new benzo-[d]-oxazole derivatives of [17(20)E]-21-norpregnene, differing in the structure of steroid moiety, were synthesized and evaluated for their potency to inhibit 17α-hydroxylase/17,20-lyase (CYP17A1) activity. Among...
10.
Kostin V, Zolottsev V, Kuzikov A, Masamrekh R, Shumyantseva V, Veselovsky A, et al.
Steroids
. 2016 Aug;
115:114-122.
PMID: 27505042
Five 4,5-dihydro-1,3-oxazole derivatives of [17(20)E]-21-norpregnene, comprising 3β-hydroxy-5-ene (1), 3,6-dioxo-4-ene (2), 3-oxo-4-ene (3), 3α,5α-cyclo-6-oxo (4), 3β-hydroxy-6-oxo (5) fragments were synthesized. Synthesis was conducted with improved procedure, based on reaction of suitably...