Alexander Wepf
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Explore the profile of Alexander Wepf including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
765
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0
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Recent Articles
1.
Abela I, Hauser A, Schwarzmuller M, Pasin C, Kusejko K, Epp S, et al.
J Infect Dis
. 2024 Jan;
230(2):e292-e304.
PMID: 38227786
Background: Factors influencing susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain to be resolved. Using data from the Swiss HIV Cohort Study on 6270 people with human immunodeficiency...
2.
Abela I, Pasin C, Schwarzmuller M, Epp S, Sickmann M, Schanz M, et al.
Nat Commun
. 2021 Nov;
12(1):6703.
PMID: 34795285
Determination of SARS-CoV-2 antibody responses in the context of pre-existing immunity to circulating human coronavirus (HCoV) is critical for understanding protective immunity. Here we perform a multifactorial analysis of SARS-CoV-2...
3.
Orme M, Liccardi G, Moderau N, Feltham R, Wicky-John S, Tenev T, et al.
Nat Commun
. 2016 Mar;
7:10972.
PMID: 26960254
Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration. How caspases are activated under non-apoptotic conditions and process a selective set of substrates...
4.
Hauri S, Wepf A, van Drogen A, Varjosalo M, Tapon N, Aebersold R, et al.
Mol Syst Biol
. 2013 Dec;
9:713.
PMID: 24366813
Tissue homeostasis is controlled by signaling systems that coordinate cell proliferation, cell growth and cell shape upon changes in the cellular environment. Deregulation of these processes is associated with human...
5.
Pulliainen A, Pieles K, Brand C, Hauert B, Bohm A, Quebatte M, et al.
Proc Natl Acad Sci U S A
. 2012 May;
109(24):9581-6.
PMID: 22635269
Subversion of host organism cAMP signaling is an efficient and widespread mechanism of microbial pathogenesis. Bartonella effector protein A (BepA) of vasculotumorigenic Bartonella henselae protects the infected human endothelial cells...
6.
Glatter T, Schittenhelm R, Rinner O, Roguska K, Wepf A, Junger M, et al.
Mol Syst Biol
. 2011 Nov;
7:547.
PMID: 22068330
Genetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode...
7.
Ribeiro P, Josue F, Wepf A, Wehr M, Rinner O, Kelly G, et al.
Mol Cell
. 2010 Aug;
39(4):521-34.
PMID: 20797625
The Hippo (Hpo) pathway is a central determinant of tissue size in both Drosophila and higher organisms. The core of the pathway is a kinase cascade composed of an upstream...
8.
Langton P, Colombani J, Chan E, Wepf A, Gstaiger M, Tapon N
Curr Biol
. 2009 Nov;
19(23):1969-78.
PMID: 19931458
Background: Adherens junctions (AJs) provide structure to epithelial tissues by connecting adjacent cells through homophilic E-cadherin interactions and are linked to the actin cytoskeleton via the intermediate binding proteins beta-catenin...
9.
Wepf A, Glatter T, Schmidt A, Aebersold R, Gstaiger M
Nat Methods
. 2009 Feb;
6(3):203-5.
PMID: 19198594
We present a mass spectrometry-based strategy for the absolute quantification of protein complex components isolated through affinity purification. We quantified bait proteins via isotope-labeled reference peptides corresponding to an affinity...
10.
Glatter T, Wepf A, Aebersold R, Gstaiger M
Mol Syst Biol
. 2009 Jan;
5:237.
PMID: 19156129
Protein complexes represent major functional units for the execution of biological processes. Systematic affinity purification coupled with mass spectrometry (AP-MS) yielded a wealth of information on the compendium of protein...