Alexander W Bird
Overview
Explore the profile of Alexander W Bird including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1376
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0
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Recent Articles
1.
Singh D, Schmidt N, Muller F, Bange T, Bird A
Curr Biol
. 2020 Dec;
31(4):766-781.e8.
PMID: 33333009
The precise regulation of microtubule dynamics over time and space in dividing cells is critical for several mitotic mechanisms that ultimately enable cell proliferation, tissue organization, and development. Astral microtubules,...
2.
Rondelet A, Pozniakovsky A, Namboodiri D, Cardoso da Silva R, Singh D, Leuschner M, et al.
Life Sci Alliance
. 2020 Dec;
4(2).
PMID: 33293335
Bacterial artificial chromosome (BAC)-based transgenes have emerged as a powerful tool for controlled and conditional interrogation of protein function in higher eukaryotes. Although homologous recombination-based recombineering methods have streamlined the...
3.
Polverino F, Naso F, Asteriti I, Palmerini V, Singh D, Valente D, et al.
Curr Biol
. 2020 Dec;
31(3):658-667.e5.
PMID: 33275894
Mitotic spindle orientation is a crucial process that defines the axis of cell division, contributing to daughter cell positioning and fate, and hence to tissue morphogenesis and homeostasis. The trimeric...
4.
Rondelet A, Lin Y, Singh D, Porfetye A, Thakur H, Hecker A, et al.
J Cell Biol
. 2020 Jan;
219(2).
PMID: 31932847
Clathrin ensures mitotic spindle stability and efficient chromosome alignment, independently of its vesicle trafficking function. Although clathrin localizes to the mitotic spindle and kinetochore fiber microtubule bundles, the mechanisms by...
5.
Zhang K, Foster H, Rondelet A, Lacey S, Bahi-Buisson N, Bird A, et al.
Cell
. 2017 Jun;
169(7):1303-1314.e18.
PMID: 28602352
Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its...
6.
Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, et al.
Elife
. 2017 Jan;
6.
PMID: 28059702
Centromeres are unique chromosomal loci that promote the assembly of kinetochores, macromolecular complexes that bind spindle microtubules during mitosis. In most organisms, centromeres lack defined genetic features. Rather, they are...
7.
Bendre S, Rondelet A, Hall C, Schmidt N, Lin Y, Brouhard G, et al.
J Cell Biol
. 2016 Nov;
215(5):631-647.
PMID: 27881713
The dynamic regulation of microtubules (MTs) during mitosis is critical for accurate chromosome segregation and genome stability. Cancer cell lines with hyperstabilized kinetochore MTs have increased segregation errors and elevated...
8.
Scolz M, Widlund P, Piazza S, Bublik D, Reber S, Peche L, et al.
PLoS One
. 2012 Dec;
7(12):e51259.
PMID: 23236459
The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules...
9.
Ross K, Sedello A, Todd G, Paszkowski-Rogacz M, Bird A, Ding L, et al.
Blood
. 2012 Mar;
119(18):4152-61.
PMID: 22411870
The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the...
10.
Aguirre-Portoles C, Bird A, Hyman A, Canamero M, Perez de Castro I, Malumbres M
Cancer Res
. 2012 Jan;
72(6):1518-28.
PMID: 22266221
Tpx2 is a microtubule-associated protein that activates the cell-cycle kinase Aurora A and regulates the mitotic spindle. Overexpression of Tpx2 is associated with the development of different human tumors and...