Alexander von Kriegsheim
Overview
Explore the profile of Alexander von Kriegsheim including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
955
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Recent Articles
1.
Valcikova B, Vadovicova N, Smolkova K, Zacpalova M, Krejci P, Lee S, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(44):e2321305121.
PMID: 39436655
The eIF4F translation initiation complex plays a critical role in melanoma resistance to clinical BRAF and MEK inhibitors. In this study, we uncover a function of eIF4F in the negative...
2.
de la Fuente-Vivas D, Cappitelli V, Garcia-Gomez R, Valero-Diaz S, Amato C, Rodriguez J, et al.
Mol Oncol
. 2024 Sep;
19(2):452-473.
PMID: 39263917
ERK1/2 mitogen-activated protein kinases (ERK) are key regulators of basic cellular processes, including proliferation, survival, and migration. Upon phosphorylation, ERK becomes activated and a portion of it dimerizes. The importance...
3.
Raab M, Christodoulou E, Krishnankutty R, Gradinaru A, Walker A, Olaizola P, et al.
J Hepatol
. 2024 Mar;
81(1):108-119.
PMID: 38460794
Background & Aims: In the developing liver, bipotent epithelial progenitor cells undergo lineage segregation to form hepatocytes, which constitute the bulk of the liver parenchyma, and biliary epithelial cells (cholangiocytes),...
4.
Hooftman A, Peace C, Ryan D, Day E, Yang M, Mcgettrick A, et al.
Nature
. 2023 Mar;
615(7952):490-498.
PMID: 36890227
Metabolic rewiring underlies the effector functions of macrophages, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory aspartate-argininosuccinate shunt...
5.
Chu L, Arede P, Li W, Urdaneta E, Ivanova I, McKellar S, et al.
Nat Commun
. 2022 May;
13(1):2883.
PMID: 35610211
RNA-binding proteins play key roles in controlling gene expression in many organisms, but relatively few have been identified and characterised in detail in Gram-positive bacteria. Here, we globally analyse RNA-binding...
6.
Quinn N, Garcia-Gutierrez L, Doherty C, von Kriegsheim A, Fallahi E, Sacks D, et al.
Cells
. 2021 Mar;
10(2).
PMID: 33672268
The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of...
7.
The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets
Comer S, Nagy Z, Bolado A, von Kriegsheim A, Gambaryan S, Walter U, et al.
J Thromb Haemost
. 2020 Jul;
18(11):3002-3012.
PMID: 32692911
Background: Circulating platelets are maintained in an inactive state by the endothelial lining of the vasculature. Endothelium-derived prostacyclin and nitric oxide stimulate cAMP- and cGMP-dependent kinases, PKA and PKG, to...
8.
Butepage M, Preisinger C, von Kriegsheim A, Scheufen A, Lausberg E, Li J, et al.
Sci Rep
. 2018 May;
8(1):6748.
PMID: 29712969
Macrodomains are conserved protein folds associated with ADP-ribose binding and turnover. ADP-ribosylation is a posttranslational modification catalyzed primarily by ARTD (aka PARP) enzymes in cells. ARTDs transfer either single or...
9.
Magi S, Iwamoto K, Yumoto N, Hiroshima M, Nagashima T, Ohki R, et al.
J Biol Chem
. 2017 Dec;
293(6):2206-2218.
PMID: 29233889
Feedback control is a key mechanism in signal transduction, intimately involved in regulating the outcome of the cellular response. Here, we report a novel mechanism by which PHLDA1, Pleckstrin homology-like...
10.
Sun C, de Mello V, Mohamed A, Ortuste Quiroga H, Garcia-Munoz A, Al Bloshi A, et al.
Stem Cells
. 2017 Jun;
35(8):1958-1972.
PMID: 28589555
Hippo pathway downstream effectors Yap and Taz play key roles in cell proliferation and regeneration, regulating gene expression especially via Tead transcription factors. To investigate their role in skeletal muscle...