Alexander Vargas-Hernandez
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Explore the profile of Alexander Vargas-Hernandez including associated specialties, affiliations and a list of published articles.
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25
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667
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Recent Articles
1.
Sakthivel D, Brown-Suedel A, Lopez K, Salgar S, Coutinho L, Keane F, et al.
Sci Adv
. 2024 Aug;
10(31):eadj3145.
PMID: 39093977
Mutation in nucleophosmin (NPM1) causes relocalization of this normally nucleolar protein to the cytoplasm (NPM1c+). Despite NPM1 mutation being the most common driver mutation in cytogenetically normal adult acute myeloid...
2.
Smith M, Forbes Satter L, Vargas-Hernandez A
Front Immunol
. 2023 Feb;
13:1025373.
PMID: 36755813
The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in immune regulation and homeostasis and play a crucial role in the development and function of several hematopoietic cells....
3.
Leiding J, Vogel T, Santarlas V, Mhaskar R, Smith M, Carisey A, et al.
J Allergy Clin Immunol
. 2022 Oct;
151(4):1081-1095.
PMID: 36228738
Background: In 2014, germline signal transducer and activator of transcription (STAT) 3 gain-of-function (GOF) mutations were first described to cause a novel multisystem disease of early-onset lymphoproliferation and autoimmunity. Objective:...
4.
Pelham S, Caldirola M, Avery D, Mackie J, Rao G, Gothe F, et al.
J Allergy Clin Immunol
. 2022 Apr;
150(4):931-946.
PMID: 35469842
Background: Lymphocyte differentiation is regulated by coordinated actions of cytokines and signaling pathways. IL-21 activates STAT1, STAT3, and STAT5 and is fundamental for the differentiation of human B cells into...
5.
Angelo L, Hogg G, Abeynaike S, Bimler L, Vargas-Hernandez A, Paust S
Front Immunol
. 2022 Feb;
12:810080.
PMID: 35173710
Human NK cells are comprised of phenotypic subsets, whose potentially unique functions remain largely unexplored. C-X-C-motif-chemokine-receptor-6 (CXCR6) NK cells have been identified as phenotypically immature tissue-resident NK cells in mice...
6.
Cook S, Comrie W, Poli M, Similuk M, Oler A, Faruqi A, et al.
Science
. 2020 Jul;
369(6500):202-207.
PMID: 32647003
Immunodeficiency often coincides with hyperactive immune disorders such as autoimmunity, lymphoproliferation, or atopy, but this coincidence is rarely understood on a molecular level. We describe five patients from four families...
7.
Kuhny M, Forbes L, Cakan E, Vega-Loza A, Kostiuk V, Dinesh R, et al.
J Clin Invest
. 2020 Jun;
130(8):4411-4422.
PMID: 32484799
Patients with common variable immunodeficiency associated with autoimmune cytopenia (CVID+AIC) generate few isotype-switched B cells with severely decreased frequencies of somatic hypermutations (SHMs), but their underlying molecular defects remain poorly...
8.
Vargas-Hernandez A, Witalisz-Siepracka A, Prchal-Murphy M, Klein K, Mahapatra S, Al-Herz W, et al.
J Allergy Clin Immunol
. 2019 Oct;
145(1):345-357.e9.
PMID: 31600547
Background: Patients with signal transducer and activator of transcription 5b (STAT5b) deficiency have impairment in T-cell homeostasis and natural killer (NK) cells which leads to autoimmunity, recurrent infections, and combined...
9.
Aird A, Lagos M, Vargas-Hernandez A, Posey J, Coban-Akdemir Z, Jhangiani S, et al.
Front Pediatr
. 2019 Aug;
7:303.
PMID: 31417880
Nuclear factor kappa-B subunit 2 (NF-κB2/p100/p52), encoded by (MIM: 164012) belongs to the NF-κB family of transcription factors that play a critical role in inflammation, immunity, cell proliferation, differentiation and...
10.
Henrickson S, Dolan J, Forbes L, Vargas-Hernandez A, Nishimura S, Okada S, et al.
Front Pediatr
. 2019 May;
7:160.
PMID: 31114772
In this report, we describe a novel T437N STAT1 mutation found in a mother and 3 of her 4 children which we demonstrate yields gain-of-function. All of the four patients...