Alexander Strong
Overview
Explore the profile of Alexander Strong including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
670
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Recent Articles
1.
Fischer A, Lersch R, de Andrade Kratzig N, Strong A, Friedrich M, Weber J, et al.
Cell Genom
. 2023 Mar;
3(3):100276.
PMID: 36950387
In contrast to mono- or biallelic loss of tumor-suppressor function, effects of discrete gene dysregulations, as caused by non-coding (epi)genome alterations, are poorly understood. Here, by perturbing the regulatory genome...
2.
Noorani I, de la Rosa J, Choi Y, Strong A, Ponstingl H, Vijayabaskar M, et al.
Genome Biol
. 2020 Aug;
21(1):206.
PMID: 32799926
An amendment to this paper has been published and can be accessed via the original article.
3.
Noorani I, de la Rosa J, Choi Y, Strong A, Ponstingl H, Vijayabaskar M, et al.
Genome Biol
. 2020 Jul;
21(1):181.
PMID: 32727536
Background: Glioma is the most common intrinsic brain tumor and also occurs in the spinal cord. Activating EGFR mutations are common in IDH1 wild-type gliomas. However, the cooperative partners of...
4.
Weber J, de la Rosa J, Grove C, Schick M, Rad L, Baranov O, et al.
Nat Commun
. 2019 Mar;
10(1):1415.
PMID: 30926791
B-cell lymphoma (BCL) is the most common hematologic malignancy. While sequencing studies gave insights into BCL genetics, identification of non-mutated cancer genes remains challenging. Here, we describe PiggyBac transposon tools...
5.
de la Rosa J, Weber J, Friedrich M, Li Y, Rad L, Ponstingl H, et al.
Nat Genet
. 2017 Mar;
49(5):730-741.
PMID: 28319090
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional mutagenesis screen in...
6.
Friedrich M, Rad L, Bronner I, Strong A, Wang W, Weber J, et al.
Nat Protoc
. 2017 Jan;
12(2):289-309.
PMID: 28079877
Transposon-mediated forward genetics screening in mice has emerged as a powerful tool for cancer gene discovery. It pinpoints cancer drivers that are difficult to find with other approaches, thus complementing...
7.
Maresch R, Mueller S, Veltkamp C, Ollinger R, Friedrich M, Heid I, et al.
Nat Commun
. 2016 Feb;
7:10770.
PMID: 26916719
Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited by the long duration of allele/model generation. Here we show transfection-based multiplexed delivery of CRISPR/Cas9 to the pancreas...
8.
Weber J, Ollinger R, Friedrich M, Ehmer U, Barenboim M, Steiger K, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(45):13982-7.
PMID: 26508638
Here, we show CRISPR/Cas9-based targeted somatic multiplex-mutagenesis and its application for high-throughput analysis of gene function in mice. Using hepatic single guide RNA (sgRNA) delivery, we targeted large gene sets...
9.
Dietlein F, Kalb B, Jokic M, Noll E, Strong A, Tharun L, et al.
Cell
. 2015 Jul;
162(1):146-59.
PMID: 26140595
KRAS is one of the most frequently mutated oncogenes in human cancer. Despite substantial efforts, no clinically applicable strategy has yet been developed to effectively treat KRAS-mutant tumors. Here, we...
10.
Rad R, Rad L, Wang W, Strong A, Ponstingl H, Bronner I, et al.
Nat Genet
. 2014 Dec;
47(1):47-56.
PMID: 25485836
Here we describe a conditional piggyBac transposition system in mice and report the discovery of large sets of new cancer genes through a pancreatic insertional mutagenesis screen. We identify Foxp1...