Alexander Staruschenko
Overview
Explore the profile of Alexander Staruschenko including associated specialties, affiliations and a list of published articles.
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Articles
177
Citations
3370
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Recent Articles
11.
Thomas L, Dissanayake L, Tahmasbi M, Staruschenko A, Al-Masri S, Dominguez Rieg J, et al.
Sci Rep
. 2024 Jul;
14(1):16997.
PMID: 39043847
Vitamin D is clinically used for the treatment of vitamin D deficiency or osteoporosis, partially because of its role in regulating phosphate (P) and calcium (Ca) homeostasis. The renal sodium-phosphate...
12.
Semenikhina M, Bohovyk R, Fedoriuk M, Stefanenko M, Klemens C, Oates J, et al.
Am J Physiol Renal Physiol
. 2024 Jul;
327(3):F532-F542.
PMID: 39024356
Nitric oxide (NO) is widely recognized for its role in regulating renal function and blood pressure. However, the precise mechanisms by which NO affects renal epithelial cells remain understudied. Our...
13.
Stefanenko M, Fedoriuk M, Mamenko M, Semenikhina M, Nowling T, Lipschutz J, et al.
Function (Oxf)
. 2024 Jul;
5(5).
PMID: 38984988
Mesangial cells offer structural support to the glomerular tuft and regulate glomerular capillary flow through their contractile capabilities. These cells undergo phenotypic changes, such as proliferation and mesangial expansion, resulting...
14.
Yang C, Isaeva E, Shimada S, Kurth T, Stumpf M, Zheleznova N, et al.
Am J Physiol Renal Physiol
. 2024 May;
327(3):F435-F449.
PMID: 38779754
We have previously observed that prolonged administration of rapamycin, an inhibitor targeting the mammalian target of rapamycin complex (mTORC)1, partially reduced hypertension and alleviated kidney inflammation in Dahl salt-sensitive (SS)...
15.
Staruschenko A
Am J Physiol Renal Physiol
. 2024 May;
326(6):F1039-F1040.
PMID: 38695073
No abstract available.
16.
Staruschenko A, Alexander R, Caplan M, Ilatovskaya D
Nat Rev Nephrol
. 2024 Apr;
20(8):541-555.
PMID: 38641658
The kidney plays a pivotal role in regulating calcium levels within the body. Approximately 98% of the filtered calcium is reabsorbed in the nephron, and this process is tightly controlled...
17.
Dissanayake L, Palygin O, Staruschenko A
Curr Opin Nephrol Hypertens
. 2024 Apr;
33(4):441-446.
PMID: 38639736
Purpose Of Review: Salt-sensitive (SS) hypertension and its associated kidney damage have been extensively studied, yet proper therapeutic strategies are lacking. The interest in altering the metabolome to affect renal...
18.
Dissanayake L, Kravtsova O, Lowe M, McCrorey M, Van Beusecum J, Palygin O, et al.
Clin Sci (Lond)
. 2024 Feb;
138(5):269-288.
PMID: 38358003
The development of the kidney involves essential cellular processes, such as cell proliferation and differentiation, which are led by interactions between multiple signaling pathways. Xanthine dehydrogenase (XDH) catalyzes the reaction...
19.
Billing A, Kim Y, Gullaksen S, Schrage B, Raabe J, Hutzfeldt A, et al.
Circulation
. 2023 Dec;
149(11):860-884.
PMID: 38152989
Background: SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect the kidneys and heart, but the underlying mechanism remains poorly understood. Methods: To gain insights on primary effects of SGLT2i that...
20.
Semenikhina M, Fedoriuk M, Stefanenko M, Klemens C, Cherezova A, Marshall B, et al.
Clin Sci (Lond)
. 2023 Dec;
137(24):1789-1804.
PMID: 38051199
Angiotensin receptor blockers (ARBs) are the first-line treatment for hypertension; they act by inhibiting signaling through the angiotensin 1 receptor (AT1R). Recently, a novel biased AT1R agonist, TRV120027 (TRV), which...