Alexander Semaan
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Explore the profile of Alexander Semaan including associated specialties, affiliations and a list of published articles.
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38
Citations
782
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Recent Articles
11.
Dohmen J, Semaan A, Kobilay M, Zaleski M, Branchi V, Schlierf A, et al.
Diagnostics (Basel)
. 2022 Jun;
12(6).
PMID: 35741223
Background: Despite the significance of colonoscopy for early diagnosis of colorectal adenocarcinoma (CRC), population-wide screening remains challenging, mainly because of low acceptance rates. Herein, exosomal (exo-miR) and free circulating microRNA...
12.
Lee J, Bernard V, Semaan A, Monberg M, Huang J, Stephens B, et al.
Clin Cancer Res
. 2021 Aug;
27(21):5912-5921.
PMID: 34426439
Purpose: Precision medicine approaches in pancreatic ductal adenocarcinoma (PDAC) are imperative for improving disease outcomes. With molecular subtypes of PDAC gaining relevance in the context of therapeutic stratification, the ability...
13.
Branchi V, Jurgensen B, Esser L, Gonzalez-Carmona M, Weismuller T, Strassburg C, et al.
J Pers Med
. 2021 Apr;
11(3).
PMID: 33806804
Biliary tract cancer (BTC) is characterized by an intense stromal reaction and a complex landscape of infiltrating immune cells. Evidence is emerging that tumor-infiltrating neutrophils (TINs) have an impact on...
14.
Semaan A, Bernard V, Kim D, Lee J, Huang J, Kamyabi N, et al.
Br J Cancer
. 2021 Mar;
124(12):1970-1977.
PMID: 33785875
Background: Limited accessibility of the tumour precludes longitudinal characterisation for therapy guidance in pancreatic ductal adenocarcinoma (PDAC). Methods: We utilised dielectrophoresis-field flow fractionation (DEP-FFF) to isolate circulating tumour cells (CTCs)...
15.
Henn J, Lingohr P, Branchi V, Semaan A, von Websky M, Glowka T, et al.
Front Surg
. 2021 Feb;
7:588228.
PMID: 33521045
Severe acute pancreatitis (SAP) is a heterogeneous and life-threatening disease. While recent guidelines recommend a stepwise approach starting with non-surgical techniques, emergency laparotomy remains inevitable in certain situations. Open abdomen...
16.
Semaan A, Bernard V, Lee J, Wong J, Huang J, Swartzlander D, et al.
Clin Cancer Res
. 2020 Nov;
27(4):1082-1093.
PMID: 33188144
Purpose: Most patients with pancreatic ductal adenocarcinoma (PDAC) present with surgically unresectable cancer. As a result, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the most common biospecimen source available for diagnosis...
17.
Cazacu I, Semaan A, Stephens B, Swartzlander D, Guerrero P, Singh B, et al.
Gastrointest Endosc
. 2020 Oct;
93(5):1142-1151.e2.
PMID: 33058885
Background And Aims: EUS-guided FNA is recommended as a first-line procedure for the histopathologic diagnosis of pancreatic cancer. Molecular analysis of EUS-FNA samples might be used as an auxiliary tool...
18.
Branchi V, Weismuller T, Zhou T, Henn J, Semaan A, Glowka T, et al.
Chirurg
. 2020 Jun;
92(2):148-157.
PMID: 32488382
Background: In recent years substantial progress has been made in the treatment, surveillance and understanding of the pathogenesis of primary sclerosing cholangitis (PSC); however, in most cases liver transplantation (LTX)...
19.
A microfluidic device for label-free isolation of tumor cell clusters from unprocessed blood samples
Kamyabi N, Huang J, Lee J, Bernard V, Semaan A, Stephens B, et al.
Biomicrofluidics
. 2019 Aug;
13(4):044111.
PMID: 31462955
Primary cancers disseminate both single circulating tumor cells (CTCs) and CTC "clusters," the latter of which have been shown to demonstrate greater metastatic propensity and adverse impact on prognosis. Many...
20.
Lingohr P, Dohmen J, Semaan A, Branchi V, Dietrich J, Bootz F, et al.
Epigenomics
. 2019 Mar;
11(6):639-653.
PMID: 30821175
We investigated the significance of DNA methylation in gastric adenocarcinomas. We analyzed the methylation at different CpG sites within the PD-L2-encoding gene with regard to correlations and associations with gene...