Alexander Pflug
Overview
Explore the profile of Alexander Pflug including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
949
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Recent Articles
11.
Pieroh P, Hoch A, Hohmann T, Gras F, Mardian S, Pflug A, et al.
J Bone Joint Surg Am
. 2019 Jun;
101(11):987-994.
PMID: 31169575
Background: The fragility fractures of the pelvis (FFP) classification was established to address the specific fracture morphology and dynamic instability in the elderly. Although this system is frequently used, data...
12.
Pflug A, Gaudon S, Resa-Infante P, Lethier M, Reich S, Schulze W, et al.
Nucleic Acids Res
. 2017 Dec;
46(2):956-971.
PMID: 29202182
Influenza polymerase uses short capped primers snatched from nascent Pol II transcripts to initiate transcription of viral mRNAs. Here we describe crystal structures of influenza A and B polymerase bound...
13.
Pflug A, Lukarska M, Resa-Infante P, Reich S, Cusack S
Virus Res
. 2017 Jan;
234:103-117.
PMID: 28115197
Influenza virus is a segmented, negative strand RNA virus with each genome segment being packaged in a distinct ribonucleoprotein particle (RNP). The RNP consists of the heterotrimeric viral RNA-dependent RNA...
14.
Lukarska M, Fournier G, Pflug A, Resa-Infante P, Reich S, Naffakh N, et al.
Nature
. 2016 Dec;
541(7635):117-121.
PMID: 28002402
The heterotrimeric influenza polymerase (FluPol), comprising subunits PA, PB1 and PB2, binds to the conserved 5' and 3' termini (the 'promoter') of each of the eight single-stranded viral RNA (vRNA)...
15.
Ivan T, Enkvist E, Viira B, Manoharan G, Raidaru G, Pflug A, et al.
Bioconjug Chem
. 2016 Jul;
27(8):1900-10.
PMID: 27389935
The acknowledged potential of small-molecule therapeutics targeting disease-related protein-protein interactions (PPIs) has promoted active research in this field. The strategy of using small molecule inhibitors (SMIs) to fight strong (tight-binding)...
16.
Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, et al.
Mol Cell
. 2015 Dec;
61(1):125-37.
PMID: 26711008
Influenza virus polymerase transcribes or replicates the segmented RNA genome (vRNA) into respectively viral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3' and 5' vRNA...
17.
Reich S, Guilligay D, Pflug A, Malet H, Berger I, Crepin T, et al.
Nature
. 2014 Nov;
516(7531):361-6.
PMID: 25409151
Influenza virus polymerase uses a capped primer, derived by 'cap-snatching' from host pre-messenger RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to generate the poly(A) tail....
18.
Pflug A, Guilligay D, Reich S, Cusack S
Nature
. 2014 Nov;
516(7531):355-60.
PMID: 25409142
The influenza virus polymerase transcribes or replicates the segmented RNA genome (viral RNA) into viral messenger RNA or full-length copies. To initiate RNA synthesis, the polymerase binds to the conserved...
19.
Tosi T, Pflug A, Discola K, Neves D, Dessen A
Res Microbiol
. 2013 Apr;
164(6):605-19.
PMID: 23541478
Type III secretion systems (T3SS) are macromolecular complexes that translocate a wide number of effector proteins into eukaryotic host cells. Once within the cytoplasm, many T3SS effectors mimic the structure...
20.
Aberg E, Lund B, Pflug A, Gani O, Rothweiler U, de Oliveira T, et al.
Biol Chem
. 2012 Oct;
393(10):1121-9.
PMID: 23092797
The era of structure-based protein kinase inhibitor design began in the early 1990s with the determination of crystal structures of protein kinase A (PKA, or cyclic AMP-dependent kinase). Although many...