Alexander M Morch
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Explore the profile of Alexander M Morch including associated specialties, affiliations and a list of published articles.
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7
Citations
62
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Recent Articles
1.
Philips E, Liu J, Kvalvaag A, Morch A, Tocheva A, Ng C, et al.
Sci Immunol
. 2024 Mar;
9(93):eade6256.
PMID: 38457513
Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune...
2.
Patel A, Andre V, Eguiguren S, Barton M, Burton J, Denham E, et al.
EMBO J
. 2024 Jan;
43(1):132-150.
PMID: 38177315
Understanding cellular decisions due to receptor-ligand interactions at cell-cell interfaces has been hampered by the difficulty of independently varying the surface density of multiple different ligands. Here, we express the...
3.
Zhou X, Morch A, Dustin M
Immunity
. 2023 Jun;
56(6):1155-1157.
PMID: 37315528
Important signaling events at the immunological synapse have increasingly been linked to cis interactions between receptors on T cells. In this issue of Immunity, Zhao et al. implicate cis CD28/B7...
4.
Morch A, Schneider F
Methods Mol Biol
. 2023 Apr;
2654:61-89.
PMID: 37106176
Activation of immune cells and formation of immunological synapses (IS) rely critically on the reorganization of the plasma membrane. These highly orchestrated processes are driven by diffusion and oligomerization dynamics,...
5.
Morch A, Schneider F, Jenkins E, Santos A, Fraser S, Davis S, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(49):e2213538119.
PMID: 36454761
The sensitivity of the αβ T cell receptor (TCR) is enhanced by the coreceptors CD4 and CD8αβ, which are expressed primarily by cells of the helper and cytotoxic T cell...
6.
Morch A, Balint S, Santos A, Davis S, Dustin M
Front Cell Dev Biol
. 2020 Nov;
8:597627.
PMID: 33178706
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic development, but how they contribute to immune responses in the periphery is unclear. Coreceptors strengthen T-cell responses...
7.
Harrison T, Morch A, Felce J, Sakoguchi A, Reid A, Arase H, et al.
Nature
. 2020 Jul;
587(7833):309-312.
PMID: 32650338
The Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms occur when these parasites replicate in human blood. Despite the risk of immune detection, the parasite delivers...