Alexander M Binshtok
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Explore the profile of Alexander M Binshtok including associated specialties, affiliations and a list of published articles.
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40
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1586
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Recent Articles
1.
Pollak U, Avniel-Aran A, Binshtok A, Bar-Yosef O, Bronicki R, Checchia P, et al.
J Cardiovasc Pharmacol
. 2024 Mar;
83(6):537-546.
PMID: 38498618
Open-heart surgery with cardiopulmonary bypass often leads to complications including pain, systemic inflammation, and organ damage. Traditionally managed with opioids, these pain relief methods bring potential long-term risks, prompting the...
2.
Mazor Y, Engelmayer N, Nashashibi H, Rottenfusser L, Lev S, Binshtok A
Inflamm Bowel Dis
. 2024 Mar;
30(10):1843-1851.
PMID: 38478397
Background: Transient receptor potential vanilloid 1 (TRPV1) cation channels, expressed on nociceptors, are well established as key contributors to abdominal pain in inflammatory bowel disease (IBD). Previous attempts at blocking...
3.
Rayi P, Lev S, Binshtok A
Neurobiol Pain
. 2023 Nov;
14:100139.
PMID: 37927365
The excitatory and inhibitory interneurons of superficial laminae I-II of the spinal dorsal horn (SDH) receive and process pain-related information from the primary afferents and transmit it to the brain...
4.
Caspi Y, Mazar M, Kushnir Y, Mazor Y, Katz B, Lev S, et al.
Pain
. 2023 Jan;
164(6):1388-1401.
PMID: 36645177
Physiological or pathology-mediated changes in neuronal activity trigger structural plasticity of the action potential generation site-the axon initial segment (AIS). These changes affect intrinsic neuronal excitability, thus tuning neuronal and...
5.
Katz B, Zaguri R, Edvardson S, Maayan C, Elpeleg O, Lev S, et al.
J Clin Invest
. 2022 Dec;
133(3).
PMID: 36454632
BACKGROUNDChronic pain is a debilitating illness with currently limited therapy, in part due to difficulties in translating treatments derived from animal models to patients. The transient receptor potential vanilloid 1...
6.
Barkai O, Rayi P, Butterman R, Katz B, Lev S, Binshtok A
Pain
. 2022 Sep;
164(2):443-460.
PMID: 36149026
Inflammation modifies the input-output properties of peripheral nociceptive neurons such that the same stimulus produces enhanced nociceptive firing. This increased nociceptive output enters the superficial dorsal spinal cord (SDH), an...
7.
Wong C, Barkai O, Wang F, Perez C, Lev S, Cai W, et al.
J Clin Invest
. 2022 May;
132(15).
PMID: 35579957
The encoding of noxious stimuli into action potential firing is largely mediated by nociceptive free nerve endings. Tissue inflammation, by changing the intrinsic properties of the nociceptive endings, leads to...
8.
Udasin R, Sil A, Zomot E, Cohen H, Haj J, Engelmayer N, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(13):e2118160119.
PMID: 35312368
SignificanceCalcium release-activated calcium (CRAC) channels play key roles in the regulation of cellular signaling, transcription, and migration. Here, we describe the design, chemical synthesis, and characterization of photoswitchable channel inhibitors...
9.
Gershon D, Negev-Goldstein R, Abd Al Razzaq L, Lev S, Binshtok A
STAR Protoc
. 2022 Mar;
3(1):101224.
PMID: 35284836
This protocol aims to measure ion dynamics in nociceptive terminal endings in intact mice . We describe viral injection of GCaMP6s + RFP into trigeminal ganglia (TG) of mice, followed...
10.
Aleixandre-Carrera F, Engelmayer N, Ares-Suarez D, Acosta M, Belmonte C, Gallar J, et al.
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33418928
Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged...