Alexander Kuhbacher
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Explore the profile of Alexander Kuhbacher including associated specialties, affiliations and a list of published articles.
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9
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53
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Recent Articles
1.
Kuhbacher A, Birch M, Oliver J, Gsaller F
Microbiol Spectr
. 2024 Feb;
12(3):e0330423.
PMID: 38315027
Importance: Among antifungal compounds in clinical development for systemic disease, the orotomide olorofim is one of only two that target a completely new mechanism of action. Olorofim is highly potent...
2.
The cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in
Kuhbacher A, Merschak P, Haas H, Liebl M, Muller C, Gsaller F
Antimicrob Agents Chemother
. 2023 Oct;
67(11):e0091823.
PMID: 37815358
Azole antifungals remain the "gold standard" therapy for invasive aspergillosis. The world-wide emergence of isolates resistant to this drug class, however, developed into a steadily increasing threat to human health...
3.
Sastre-Velasquez L, Dallemulle A, Kuhbacher A, Baldin C, Alcazar-Fuoli L, Niedrig A, et al.
PLoS Pathog
. 2022 Dec;
18(12):e1011066.
PMID: 36574449
Invasive aspergillosis remains one of the most devastating fungal diseases and is predominantly linked to infections caused by the opportunistic human mold pathogen Aspergillus fumigatus. Major treatment regimens for the...
4.
Baldin C, Kuhbacher A, Merschak P, Wagener J, Gsaller F
Microbiol Spectr
. 2022 Nov;
10(6):e0367022.
PMID: 36350143
Inducible promoters are indispensable elements when considering the possibility to modulate gene expression on demand. Desirable traits of conditional expression systems include their capacity for tight downregulation, high overexpression, and...
5.
Kuhbacher A, Peiffer M, Hortschansky P, Merschak P, Bromley M, Haas H, et al.
Microbiol Spectr
. 2022 May;
10(3):e0120922.
PMID: 35575535
Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase...
6.
Pfister J, Petrik M, Bendova K, Matuszczak B, Binder U, Misslinger M, et al.
J Fungi (Basel)
. 2021 Aug;
7(7).
PMID: 34356941
Invasive pulmonary aspergillosis (IPA) is a life-threatening form of fungal infection, primarily in immunocompromised patients and associated with significant mortality. Diagnostic procedures are often invasive and/or time consuming and existing...
7.
Baldin C, Kuhbacher A, Merschak P, Sastre-Velasquez L, Abt B, Dietl A, et al.
J Fungi (Basel)
. 2021 Jul;
7(7).
PMID: 34202756
The hygromycin B phosphotransferase gene from and the pyrithiamine resistance gene from are two dominant selectable marker genes widely used to genetically manipulate several fungal species. Despite the recent development...
8.
Czajlik A, Holzknecht J, Galgoczy L, Toth L, Poor P, Ordog A, et al.
Int J Mol Sci
. 2021 Jan;
22(3).
PMID: 33504082
The genome of Q176 contains a gene coding for the 88-amino-acid (aa)-long glycine- and cysteine-rich antifungal protein C (PAFC). After maturation, the secreted antifungal miniprotein (MP) comprises 64 aa and...
9.
Holzknecht J, Kuhbacher A, Papp C, Farkas A, Varadi G, Marcos J, et al.
J Fungi (Basel)
. 2020 Aug;
6(3).
PMID: 32824977
Small, cysteine-rich and cationic antimicrobial proteins (AMPs) from filamentous ascomycetes promise treatment alternatives to licensed antifungal drugs. In this study, we characterized the Q176 antifungal protein C (PAFC), which is...