Alexander Kouzmenko
Overview
Explore the profile of Alexander Kouzmenko including associated specialties, affiliations and a list of published articles.
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20
Citations
575
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Recent Articles
1.
Nishimura K, Mori J, Sawada T, Nomura S, Kouzmenko A, Yamashita K, et al.
Res Rep Urol
. 2021 Sep;
13:705-713.
PMID: 34549035
Introduction: Although the ability of androgens to promote prostate cancer development has been known for decades, the molecular mechanisms of androgen receptor (AR) signaling in the tumorigenesis remain unclear. Enhancer...
2.
Sawada T, Nishimura K, Mori J, Kanemoto Y, Kouzmenko A, Amano R, et al.
Biosci Biotechnol Biochem
. 2021 Jul;
85(10):2121-2130.
PMID: 34297060
Androgen induces the binding of its receptor (AR) to androgen-responsive elements (AREs), while genome-wide studies showed that most androgen-induced AR binding sites on chromatin were unrelated to AREs. Enhancer RNAs...
3.
Sawatsubashi S, Nishimura K, Mori J, Kouzmenko A, Kato S
J Bone Metab
. 2019 Mar;
26(1):3-12.
PMID: 30899718
Vitamin D (VD) is essential for bone health, and VD or its analogues are widely used in clinics to ameliorate bone loss. The targets and mode of VD anti-osteoporotic actions...
4.
Tokiwa S, Shimmura H, Nomura S, Watanabe R, Kurita M, Yoshida N, et al.
Res Rep Urol
. 2017 Dec;
9:225-232.
PMID: 29264358
Introduction: Therapeutically induced androgen deficiency (AD) is a standard treatment for patients with prostate cancer, but it is often associated with various adverse effects (AEs) that may lead to discontinuation....
5.
Kato S, Ishii T, Kouzmenko A
Bonekey Rep
. 2015 Jul;
4:715.
PMID: 26157578
Coordinated post-translational modifications (PTMs) of nucleosomal histones emerge as a key mechanism of gene regulation by defining chromatin configuration. Patterns of histone modifications vary in different cells and constitute core...
6.
Imai Y, Youn M, Inoue K, Takada I, Kouzmenko A, Kato S
Physiol Rev
. 2013 Apr;
93(2):481-523.
PMID: 23589826
During the last decade, our view on the skeleton as a mere solid physical support structure has been transformed, as bone emerged as a dynamic, constantly remodeling tissue with systemic...
7.
Matsumoto T, Sakari M, Okada M, Yokoyama A, Takahashi S, Kouzmenko A, et al.
Annu Rev Physiol
. 2012 Nov;
75:201-24.
PMID: 23157556
Androgens play pivotal roles in the regulation of male development and physiological processes, particularly in the male reproductive system. Most biological effects of androgens are mediated by the action of...
8.
Ito S, Fujiyama-Nakamura S, Kimura S, Lim J, Kamoshida Y, Shiozaki-Sato Y, et al.
Mol Cell
. 2012 Feb;
45(4):494-504.
PMID: 22365829
Cell cycle-dependent expression of canonical histone proteins enables newly synthesized DNA to be integrated into chromatin in replicating cells. However, the molecular basis of cell cycle-dependency in the switching of...
9.
Kouzmenko A, Ohtake F, Fujiki R, Kato S
Epigenomics
. 2011 Nov;
2(6):765-74.
PMID: 22122081
Methylation and demethylation of cytosine residues in the genomic DNA play key roles in a wide range of fundamental biological processes such as differentiation and development, genome stability, imprinting, X...
10.
Imai Y, Kouzmenko A, Kato S
Expert Opin Ther Targets
. 2011 Jul;
15(10):1143-5.
PMID: 21736533
The treatment of osteoporosis has been a critical issue in today's medical situation. Various therapeutic agents and strategies have been investigated and applied, and have proven successful in the treatment...