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Alexander Kertser

Explore the profile of Alexander Kertser including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 1106
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Recent Articles
1.
Alfahel L, Gschwendtberger T, Kozareva V, Dumas L, Gibbs R, Kertser A, et al.
Cell Rep Med . 2024 May; 5(5):101546. PMID: 38703766
Mutations in SOD1 cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by motor neuron (MN) loss. We previously discovered that macrophage migration inhibitory factor (MIF), whose levels are extremely...
2.
Ben-Yehuda H, Matcovitch-Natan O, Kertser A, Spinrad A, Prinz M, Amit I, et al.
Mol Psychiatry . 2019 Nov; 25(5):1050-1067. PMID: 31772304
Viral infection during pregnancy is often associated with neuropsychiatric conditions. In mice, exposure of pregnant dams to the viral mimetic poly(I:C), serves as a model that simulates such pathology in...
3.
Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, et al.
Nat Commun . 2017 Sep; 8(1):717. PMID: 28959042
During ageing, microglia acquire a phenotype that may negatively affect brain function. Here we show that ageing microglial phenotype is largely imposed by interferon type I (IFN-I) chronically present in...
4.
Baruch K, Deczkowska A, Rosenzweig N, Tsitsou-Kampeli A, Sharif A, Matcovitch-Natan O, et al.
Nat Med . 2016 Jan; 22(2):135-7. PMID: 26779813
Systemic immune suppression may curtail the ability to mount the protective, cell-mediated immune responses that are needed for brain repair. By using mouse models of Alzheimer's disease (AD), we show...
5.
Baruch K, Rosenzweig N, Kertser A, Deczkowska A, Sharif A, Spinrad A, et al.
Nat Commun . 2015 Aug; 6:7967. PMID: 26284939
Alzheimer's disease (AD) is a neurodegenerative disorder in which chronic neuroinflammation contributes to disease escalation. Nevertheless, while immunosuppressive drugs have repeatedly failed in treating this disease, recruitment of myeloid cells...
6.
Baruch K, Kertser A, Porat Z, Schwartz M
EMBO J . 2015 May; 34(13):1816-28. PMID: 25940071
Chronic neuroinflammation is evident in brain aging and neurodegenerative disorders and is often associated with excessive nitric oxide (NO) production within the central nervous system (CNS). Under such conditions, increased...
7.
Baruch K, Deczkowska A, David E, Castellano J, Miller O, Kertser A, et al.
Science . 2014 Aug; 346(6205):89-93. PMID: 25147279
Aging-associated cognitive decline is affected by factors produced inside and outside the brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid plexus, an interface between...
8.
Kunis G, Baruch K, Rosenzweig N, Kertser A, Miller O, Berkutzki T, et al.
Brain . 2013 Oct; 136(Pt 11):3427-40. PMID: 24088808
Infiltrating T cells and monocyte-derived macrophages support central nervous system repair. Although infiltration of leucocytes to the injured central nervous system has recently been shown to be orchestrated by the...