Alexander J Pak
Overview
Explore the profile of Alexander J Pak including associated specialties, affiliations and a list of published articles.
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35
Citations
500
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Recent Articles
1.
Cecil A, Sogues A, Gurumurthi M, Lane K, Remaut H, Pak A
PNAS Nexus
. 2024 Dec;
3(12):pgae538.
PMID: 39660065
Nanobody (Nb)-induced disassembly of surface array protein (Sap) S-layers, a two-dimensional paracrystalline protein lattice from , has been presented as a therapeutic intervention for lethal anthrax infections. However, only a...
2.
Sogues A, Leigh K, Halingstad E, Van der Verren S, Cecil A, Fioravanti A, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(51):e2415351121.
PMID: 39652757
is a spore-forming gram-positive bacterium responsible for anthrax, an infectious disease with a high mortality rate and a target of concern due to bioterrorism and long-term site contamination. The entire...
3.
Britton D, Christians L, Liu C, Legocki J, Xiao Y, Meleties M, et al.
Biomacromolecules
. 2024 Apr;
25(5):3214.
PMID: 38630987
No abstract available.
4.
Christians L, Halingstad E, Kram E, Okolovitch E, Pak A
J Phys Chem B
. 2024 Feb;
128(6):1394-1406.
PMID: 38316012
Molecular simulations of biomacromolecules that assemble into multimeric complexes remain a challenge due to computationally inaccessible length and time scales. Low-resolution and implicit-solvent coarse-grained modeling approaches using traditional nonbonded interactions...
5.
Britton D, Christians L, Liu C, Legocki J, Xiao Y, Meleties M, et al.
Biomacromolecules
. 2023 Dec;
25(1):258-271.
PMID: 38110299
Protein hydrogels represent an important and growing biomaterial for a multitude of applications, including diagnostics and drug delivery. We have previously explored the ability to engineer the thermoresponsive supramolecular assembly...
6.
Janssens A, Nguyen V, Cecil A, Van der Verren S, Timmerman E, Deghelt M, et al.
Nature
. 2023 Dec;
626(7999):617-625.
PMID: 38081298
The outer membrane in Gram-negative bacteria consists of an asymmetric phospholipid-lipopolysaccharide bilayer that is densely packed with outer-membrane β-barrel proteins (OMPs) and lipoproteins. The architecture and composition of this bilayer...
7.
Peng Y, Pak A, Durumeric A, Sahrmann P, Mani S, Jin J, et al.
J Phys Chem B
. 2023 Oct;
127(40):8537-8550.
PMID: 37791670
The "bottom-up" approach to coarse-graining, for building accurate and efficient computational models to simulate large-scale and complex phenomena and processes, is an important approach in computational chemistry, biophysics, and materials...
8.
Gupta M, Pak A, Voth G
Sci Adv
. 2023 Jan;
9(1):eadd7434.
PMID: 36608139
The maturation of HIV-1 capsid protein (CA) into a cone-shaped lattice capsid is critical for viral infectivity. CA can self-assemble into a range of capsid morphologies made of ~175 to...
9.
Jin J, Pak A, Durumeric A, Loose T, Voth G
J Chem Theory Comput
. 2022 Sep;
18(10):5759-5791.
PMID: 36070494
Large-scale computational molecular models provide scientists a means to investigate the effect of microscopic details on emergent mesoscopic behavior. Elucidating the relationship between variations on the molecular scale and macroscopic...
10.
Pak A, Gupta M, Yeager M, Voth G
J Am Chem Soc
. 2022 Jun;
144(23):10417-10428.
PMID: 35666943
During the late stages of the HIV-1 lifecycle, immature virions are produced by the concerted activity of Gag polyproteins, primarily mediated by the capsid (CA) and spacer peptide 1 (SP1)...