Alexander Hirschi
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Explore the profile of Alexander Hirschi including associated specialties, affiliations and a list of published articles.
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10
Citations
473
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Recent Articles
1.
Senanayaka D, Zeng D, Alishiri S, Martin W, Moore K, Patel R, et al.
J Biol Chem
. 2024 Jul;
300(9):107607.
PMID: 39084460
The N-terminal region of the human lysine-specific demethylase 1 (LSD1) has no predicted structural elements, contains a nuclear localization signal (NLS), undergoes multiple posttranslational modifications (PTMs), and acts as a...
2.
Xu M, Senanayaka D, Zhao R, Chigumira T, Tripathi A, Tones J, et al.
Nat Commun
. 2024 Mar;
15(1):2165.
PMID: 38461301
The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway. Here we report that TERRA contributes to ALT via interacting...
3.
Asthana A, Ramanan P, Hirschi A, Guiley K, Wijeratne T, Shelansky R, et al.
Nat Commun
. 2022 Jan;
13(1):526.
PMID: 35082292
The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncertain how most transcription factors (TFs) impact nucleosome position. The MuvB TF complex regulates cell-cycle dependent...
4.
Abzhanova A, Hirschi A, Reiter N
J Struct Biol
. 2021 Mar;
213(2):107728.
PMID: 33753203
HOTAIR is a large, multi-exon spliced non-coding RNA proposed to function as a molecular scaffold and competes with chromatin to bind to histone modification enzymes. Previous sequence analysis and biochemical...
5.
Hirschi A, Martin W, Luka Z, Loukachevitch L, Reiter N
RNA
. 2016 Jun;
22(8):1250-60.
PMID: 27277658
Lysine-specific histone demethylase 1 (LSD1) is an essential epigenetic regulator in metazoans and requires the co-repressor element-1 silencing transcription factor (CoREST) to efficiently catalyze the removal of mono- and dimethyl...
6.
McGrath D, Balog E, Koivomagi M, Lucena R, Mai M, Hirschi A, et al.
Nat Struct Mol Biol
. 2013 Nov;
20(12):1407-14.
PMID: 24186063
Cks is an evolutionarily conserved protein that regulates cyclin-dependent kinase (CDK) activity. Clarifying the underlying mechanisms and cellular contexts of Cks function is critical because Cks is essential for proper...
7.
Schachter M, Merrick K, Larochelle S, Hirschi A, Zhang C, Shokat K, et al.
Mol Cell
. 2013 Apr;
50(2):250-60.
PMID: 23622515
Eukaryotic cell division is controlled by cyclin-dependent kinases (CDKs), which require phosphorylation by a CDK-activating kinase (CAK) for full activity. Chemical genetics uncovered requirements for the metazoan CAK Cdk7 in...
8.
Hirschi A, Cecchini M, Steinhardt R, Schamber M, Dick F, Rubin S
Nat Struct Mol Biol
. 2010 Aug;
17(9):1051-7.
PMID: 20694007
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein (Rb) are modulated by a balance of kinase and phosphatase activities. Here we characterize the association of Rb...
9.
Korostelev A, Asahara H, Lancaster L, Laurberg M, Hirschi A, Zhu J, et al.
Proc Natl Acad Sci U S A
. 2008 Dec;
105(50):19684-9.
PMID: 19064930
We report the crystal structure of a translation termination complex formed by the Thermus thermophilus 70S ribosome bound with release factor RF2, in response to a UAA stop codon, solved...
10.
Wu V, Schulte J, Hirschi A, Tepass U, Beitel G
J Cell Biol
. 2004 Jan;
164(2):313-23.
PMID: 14734539
Epithelial tubes of the correct size and shape are vital for the function of the lungs, kidneys, and vascular system, yet little is known about epithelial tube size regulation. Mutations...