Alexander Hergovich
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Explore the profile of Alexander Hergovich including associated specialties, affiliations and a list of published articles.
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65
Citations
3562
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Recent Articles
1.
Roehrig A, Klupsch K, Oses-Prieto J, Chaib S, Henderson S, Emmett W, et al.
PLoS One
. 2021 Aug;
16(8):e0254697.
PMID: 34424918
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and...
2.
Gundogdu R, Erdogan M, Ditsiou A, Spanswick V, Garcia-Gomez J, Hartley J, et al.
Cell Signal
. 2021 Aug;
87:110106.
PMID: 34363951
Monopolar spindle-one binder (MOBs) proteins are evolutionarily conserved and contribute to various cellular signalling pathways. Recently, we reported that hMOB2 functions in preventing the accumulation of endogenous DNA damage and...
3.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
4.
Tang F, Gao R, Jeevan-Raj B, Wyss C, Kalathur R, Piscuoglio S, et al.
Nat Commun
. 2019 Dec;
10(1):5755.
PMID: 31848340
Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here...
5.
Martin A, Jacquemyn M, Lipecka J, Chhuon C, Aushev V, Meunier B, et al.
EMBO Rep
. 2019 Sep;
20(11):e48150.
PMID: 31544310
STK38 (also known as NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity-labeling assay, we identify more than 250...
6.
Klimek C, Jahnke R, Wordehoff J, Kathage B, Stadel D, Behrends C, et al.
Biochim Biophys Acta Mol Cell Res
. 2019 Jul;
1866(10):1556-1566.
PMID: 31326538
Chaperone-assisted selective autophagy (CASA) initiated by the cochaperone Bcl2-associated athanogene 3 (BAG3) represents an important mechanism for the disposal of misfolded and damaged proteins in mammalian cells. Under mechanical stress,...
7.
Gundogdu R, Hergovich A
Cells
. 2019 Jun;
8(6).
PMID: 31185650
The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers...
8.
Keller M, Dubois F, Teulier S, Martin A, Levallet J, Maille E, et al.
J Exp Clin Cancer Res
. 2019 Apr;
38(1):158.
PMID: 30979377
Background: RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are partly due to the inactivation of the anti-migratory...
9.
Gomez M, Kulaberoglu Y, Hergovich A
Methods Mol Biol
. 2018 Dec;
1893:319-331.
PMID: 30565144
The Hippo tumor suppressor pathway is fundamental to the coordination of death, growth, proliferation, and differentiation on the cellular level. At the molecular level, a highly conserved Hippo core cassette...
10.
Hergovich A
Methods Mol Biol
. 2018 Dec;
1893:305-317.
PMID: 30565143
The Hippo tissue growth control and regeneration pathway is a main regulator of the YAP/TAZ effectors. In this regard, the LATS/NDR serine/threonine protein kinases can function as central components of...