Alexander Goginashvili
Overview
Explore the profile of Alexander Goginashvili including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
1782
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0
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Recent Articles
1.
Krupina K, Goginashvili A, Cleveland D
Nat Rev Genet
. 2023 Nov;
25(3):196-210.
PMID: 37938738
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of complex chromosome rearrangement is chromothripsis, a massive,...
2.
Lu S, Hu J, Aladesuyi Arogundade O, Goginashvili A, Vazquez-Sanchez S, Diedrich J, et al.
Nat Cell Biol
. 2022 Sep;
24(9):1378-1393.
PMID: 36075972
While acetylated, RNA-binding-deficient TDP-43 reversibly phase separates within nuclei into complex droplets (anisosomes) comprised of TDP-43-containing liquid outer shells and liquid centres of HSP70-family chaperones, cytoplasmic aggregates of TDP-43 are...
3.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
4.
Krupina K, Goginashvili A, Cleveland D
Curr Opin Cell Biol
. 2021 Feb;
70:91-99.
PMID: 33610905
Micronuclei are small membrane-bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have long been linked to chromosome instability, genome...
5.
Vivot K, Pasquier A, Goginashvili A, Ricci R
J Mol Biol
. 2019 Aug;
432(5):1494-1513.
PMID: 31381897
For many decades the lysosome has been recognized as the terminal center of cellular waste disposal. Products of lysosomal degradation are either recycled in biosynthetic pathways or are further metabolized...
6.
Pasquier A, Vivot K, Erbs E, Spiegelhalter C, Zhang Z, Aubert V, et al.
Nat Commun
. 2019 Jul;
10(1):3312.
PMID: 31346174
Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying β cell failure remain incompletely understood. Here,...
7.
Meszaros G, Pasquier A, Vivot K, Goginashvili A, Ricci R
Diabetes Obes Metab
. 2018 Sep;
20 Suppl 2:104-115.
PMID: 30230186
Regulated insulin secretion from pancreatic β-cells is a major process maintaining glucose homeostasis in mammals. Enhancing insulin release in response to chronic nutrient overload and obesity-related insulin resistance (pre-diabetes) requires...
8.
Zhang Z, Meszaros G, He W, Xu Y, Magliarelli H, Mailly L, et al.
J Exp Med
. 2017 Jul;
214(9):2671-2693.
PMID: 28716882
The inflammasomes are multiprotein complexes sensing tissue damage and infectious agents to initiate innate immune responses. Different inflammasomes containing distinct sensor molecules exist. The NLRP3 inflammasome is unique as it...
9.
Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal R, Artates J, Tabet R, et al.
Neuron
. 2017 Apr;
94(1):48-57.e4.
PMID: 28384474
Onset of neurodegenerative disorders, including Huntington's disease, is strongly influenced by aging. Hallmarks of aged cells include compromised nuclear envelope integrity, impaired nucleocytoplasmic transport, and accumulation of DNA double-strand breaks....
10.
Magliarelli H, Matondo M, Meszaros G, Goginashvili A, Erbs E, Zhang Z, et al.
Cell Death Dis
. 2016 Oct;
7(10):e2411.
PMID: 27735945
Adaptation to changes in nutrient availability is crucial for cells and organisms. Posttranslational modifications of signaling proteins are very dynamic and are therefore key to promptly respond to nutrient deprivation...