Alexander Goedel
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Explore the profile of Alexander Goedel including associated specialties, affiliations and a list of published articles.
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33
Citations
1401
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Recent Articles
1.
Bolesani E, Bornhorst D, Iyer L, Zawada D, Friese N, Morgan M, et al.
Cardiovasc Res
. 2024 Jun;
120(11):1295-1311.
PMID: 38836637
Aims: Understanding the molecular identity of human pluripotent stem cell (hPSC)-derived cardiac progenitors and mechanisms controlling their proliferation and differentiation is valuable for developmental biology and regenerative medicine. Methods And...
2.
Ebeling M, Muhlichen M, Talback M, Rau R, Goedel A, Klusener S
Prev Med
. 2023 Dec;
179:107833.
PMID: 38145875
Objective: Demographic and infrastructural developments might compromise medical care provision in rural regions, particularly for acute health conditions. Studying the case of myocardial infarction (MI), we investigated how MI-related mortality...
3.
Meier A, Zawada D, De Angelis M, Martens L, Santamaria G, Zengerle S, et al.
Nat Biotechnol
. 2023 Apr;
41(12):1787-1800.
PMID: 37012447
The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple cardiac cell lineages during embryonic development and provides signals that are essential to myocardial growth and...
4.
Zawada D, Kornherr J, Meier A, Santamaria G, Dorn T, Nowak-Imialek M, et al.
Nat Commun
. 2023 Apr;
14(1):1722.
PMID: 37012244
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor populations. Understanding the specification and differentiation of these distinct progenitor pools during human embryonic development is crucial for advancing our...
5.
Rohner E, Yang R, Foo K, Goedel A, Chien K
Nat Biotechnol
. 2022 Nov;
40(11):1586-1600.
PMID: 36329321
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19) has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical trials of mRNA therapeutics include...
6.
Zheng Y, Yan R, Sun S, Kobayashi M, Xiang L, Yang R, et al.
Cell Stem Cell
. 2022 Sep;
29(9):1402-1419.e8.
PMID: 36055194
Despite its clinical and fundamental importance, our understanding of early human development remains limited. Stem cell-derived, embryo-like structures (or embryoids) allowing studies of early development without using natural embryos can...
7.
Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders
Eroglu E, Yen C, Tsoi Y, Witman N, Elewa A, Araus A, et al.
Nat Cell Biol
. 2022 May;
24(5):645-658.
PMID: 35550612
The contribution of the epicardium, the outermost layer of the heart, to cardiac regeneration has remained controversial due to a lack of suitable analytical tools. By combining genetic marker-independent lineage-tracing...
8.
9.
Fomin A, Gartner A, Cyganek L, Tiburcy M, Tuleta I, Wellers L, et al.
Sci Transl Med
. 2021 Nov;
13(618):eabd3079.
PMID: 34731013
Heterozygous truncating variants in (TTNtv), the gene coding for titin, cause dilated cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease management remains uncertain. Truncated titin proteins have not...
10.
Krane M, Dressen M, Santamaria G, My I, Schneider C, Dorn T, et al.
Circulation
. 2021 Oct;
144(17):1409-1428.
PMID: 34694888
Background: Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrum of left ventricular...