Alexander Faussner
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Explore the profile of Alexander Faussner including associated specialties, affiliations and a list of published articles.
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35
Citations
426
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Recent Articles
11.
Jamasbi J, Megens R, Bianchini M, Uhland K, Munch G, Ungerer M, et al.
JACC Basic Transl Sci
. 2016 Oct;
1(3):131-142..
PMID: 27766315
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc. Cross-linking potentiated the...
12.
Mandl M, Drechsler M, Jansen Y, Neideck C, Noels H, Faussner A, et al.
PLoS One
. 2015 Aug;
10(8):e0134176.
PMID: 26252890
Background And Aims: Plasmacytoid dendritic cells (pDCs) are a small subset of dendritic cells and the main producers of type I interferons. Besides their contribution to tolerance, they are known...
13.
Jamasbi J, Megens R, Bianchini M, Munch G, Ungerer M, Faussner A, et al.
J Am Coll Cardiol
. 2015 Jun;
65(22):2404-15.
PMID: 26046734
Background: Glycoprotein VI (GPVI) is the essential platelet collagen receptor in atherothrombosis, but its inhibition causes only a mild bleeding tendency. Thus, targeting this receptor has selective antithrombotic potential. Objectives:...
14.
Kozik A, Gogol M, Bochenska O, Karkowska-Kuleta J, Wolak N, Kamysz W, et al.
BMC Microbiol
. 2015 Apr;
15:60.
PMID: 25879450
Background: Candida albicans yeast produces 10 distinct secreted aspartic proteases (Saps), which are some of the most important virulence factors of this pathogenic fungus. One of the suggested roles of...
15.
Ring L, Neth P, Weber C, Steffens S, Faussner A
Cell Signal
. 2013 Nov;
26(2):260-7.
PMID: 24269653
The WNT/β-catenin signalling cascade is the best-investigated frizzled receptor (FZD) pathway, however, whether and how specific combinations of WNT/FZD and co-receptors LRP5 and LRP6 differentially affect this pathway are not...
16.
Bras G, Bochenska O, Rapala-Kozik M, Guevara-Lora I, Faussner A, Kamysz W, et al.
Peptides
. 2013 Aug;
48:114-23.
PMID: 23954712
In terms of infection incidence, the yeast Candida parapsilosis is the second after Candida albicans as causative agent of candidiases in humans. The major virulence factors of C. parapsilosis are...
17.
Guevara-Lora I, Blonska B, Faussner A, Kozik A
Acta Biochim Pol
. 2013 Jun;
60(3):299-305.
PMID: 23757449
Kinins, a group of important pro-inflammatory peptides, are abundantly found in tissues and biological fluids of cancer patients. Bradykinin, the major representative of kinins, induces vascular permeability and, in consequence,...
18.
Leschner J, Wennerberg G, Feierler J, Bermudez M, Welte B, Kalatskaya I, et al.
J Pharmacol Exp Ther
. 2012 Oct;
344(1):85-95.
PMID: 23086229
The DRY motif with the highly conserved R3.50 is a hallmark of family A G protein-coupled receptors (GPCRs). The crystal structure of rhodopsin revealed a salt bridge between R135(3.50) and...
19.
Bras G, Bochenska O, Rapala-Kozik M, Guevara-Lora I, Faussner A, Kozik A
Biol Chem
. 2012 Sep;
393(8):829-39.
PMID: 22944684
Bradykinin-related peptides, universal mediators of inflammation collectively referred to as the kinins, are often produced in excessive amounts during microbial infections. We have recently shown that the yeast Candida albicans,...
20.
Feierler J, Wirth M, Welte B, Schussler S, Jochum M, Faussner A
J Biol Chem
. 2011 Oct;
286(50):43282-93.
PMID: 22016392
Upon activation the human bradykinin B(2) receptor (B(2)R) acts as guanine nucleotide exchange factor for the G proteins G(q/11) and G(i). Thereafter, it gets phosphorylated by G protein-coupled receptor kinases...