Alexander F Wilson
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Explore the profile of Alexander F Wilson including associated specialties, affiliations and a list of published articles.
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72
Citations
1797
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Recent Articles
1.
Nicoletti P, Zafer S, Matok L, Irron I, Patrick M, Haklai R, et al.
Genet Med Open
. 2024 Sep;
2.
PMID: 39345948
Purpose: The etiopathogenesis of coronal nonsyndromic craniosynostosis (cNCS), a congenital condition defined by premature fusion of 1 or both coronal sutures, remains largely unknown. Methods: We conducted the largest genome-wide...
2.
Wang S, Chiu C, Wilson A, Bailey-Wilson J, Agron E, Chew E, et al.
Genet Epidemiol
. 2023 Apr;
47(6):409-431.
PMID: 37101379
In genetic studies, many phenotypes have multiple naturally ordered discrete values. The phenotypes can be correlated with each other. If multiple correlated ordinal traits are analyzed simultaneously, the power of...
3.
Justice C, Musolf A, Cuellar A, Lattanzi W, Simeonov E, Kaneva R, et al.
Genes (Basel)
. 2022 May;
13(5).
PMID: 35627201
Craniosynostosis (CS) is a major birth defect in which one or more skull sutures fuse prematurely. We previously performed a genome-wide association study (GWAS) for sagittal non-syndromic CS (sNCS), identifying...
4.
Chiu C, Wang S, Zhang B, Luo Y, Simpson C, Zhang W, et al.
Genet Epidemiol
. 2022 Apr;
46(5-6):234-255.
PMID: 35438198
In this paper, we develop functional ordinal logistic regression (FOLR) models to perform gene-based analysis of ordinal traits. In the proposed FOLR models, genetic variant data are viewed as stochastic...
5.
Jiang Y, Chiu C, Yan Q, Chen W, Gorin M, Conley Y, et al.
J Am Stat Assoc
. 2021 Jul;
116(534):531-545.
PMID: 34321704
Genetics plays a role in age-related macular degeneration (AMD), a common cause of blindness in the elderly. There is a need for powerful methods for carrying out region-based association tests...
6.
Zhang B, Chiu C, Yuan F, Sang T, Cook R, Wilson A, et al.
Genet Epidemiol
. 2021 Mar;
45(5):455-470.
PMID: 33645812
Genetic studies of two related survival outcomes of a pleiotropic gene are commonly encountered but statistical models to analyze them are rarely developed. To analyze sequencing data, we propose mixed...
7.
Sung H, Hyland P, Pemov A, Sabourin J, Baldwin A, Bass S, et al.
Mol Genet Genomic Med
. 2020 Sep;
8(10):e1400.
PMID: 32869517
Background: Neurofibromatosis type 1 (NF1) is a tumor-predisposition disorder that arises due to pathogenic variants in tumor suppressor NF1. NF1 has variable expressivity that may be due, at least in...
8.
Justice C, Cuellar A, Bala K, Sabourin J, Cunningham M, Crawford K, et al.
Hum Genet
. 2020 Apr;
139(8):1077-1090.
PMID: 32266521
Our previous genome-wide association study (GWAS) for sagittal nonsyndromic craniosynostosis (sNCS) provided important insights into the genetics of midline CS. In this study, we performed a GWAS for a second...
9.
Chiu C, Zhang B, Wang S, Shao J, Lakhal-Chaieb M, Cook R, et al.
Genet Epidemiol
. 2019 Sep;
43(8):952-965.
PMID: 31502722
The importance to integrate survival analysis into genetics and genomics is widely recognized, but only a small number of statisticians have produced relevant work toward this study direction. For unrelated...
10.
Chiu C, Yuan F, Zhang B, Yuan A, Li X, Fang H, et al.
Genet Epidemiol
. 2018 Dec;
43(2):189-206.
PMID: 30537345
We develop linear mixed models (LMMs) and functional linear mixed models (FLMMs) for gene-based tests of association between a quantitative trait and genetic variants on pedigrees. The effects of a...