Alexander E Vlahos
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Explore the profile of Alexander E Vlahos including associated specialties, affiliations and a list of published articles.
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12
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152
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Recent Articles
1.
Aldrete C, Call C, SantAnna L, Vlahos A, Pei J, Cong Q, et al.
Nat Chem Biol
. 2025 Jan;
PMID: 39814991
Synthetic circuits that regulate protein secretion in human cells could support cell-based therapies by enabling control over local environments. Although protein-level circuits enable such potential clinical applications, featuring orthogonality and...
2.
Aldrete C, Call C, SantAnna L, Vlahos A, Pei J, Cong Q, et al.
bioRxiv
. 2024 Nov;
PMID: 39484520
Synthetic circuits that regulate protein secretion in human cells could support cell-based therapies by enabling control over local environments. While protein-level circuits enable such potential clinical applications, featuring orthogonality and...
3.
Aldrete C, An C, Call C, Gao X, Vlahos A
Curr Opin Biomed Eng
. 2024 Oct;
32.
PMID: 39372446
Mammalian synthetic biology aims to engineer cellular behaviors for therapeutic applications, such as enhancing immune cell efficacy against cancers or improving cell transplantation outcomes. Programming complex biological functions necessitates an...
4.
Vlahos A, Call C, Kadaba S, Guo S, Gao X
bioRxiv
. 2023 Oct;
PMID: 37873144
Synthetic biology currently holds immense potential to engineer the spatiotemporal control of intercellular signals for biomedicine. Programming behaviors using protein-based circuits has advantages over traditional gene circuits such as compact...
5.
Vlahos A, Kang J, Aldrete C, Zhu R, Chong L, Elowitz M, et al.
Nat Commun
. 2022 Feb;
13(1):912.
PMID: 35177637
To program intercellular communication for biomedicine, it is crucial to regulate the secretion and surface display of signaling proteins. If such regulations are at the protein level, there are additional...
6.
Kinney S, Ortaleza K, Vlahos A, Sefton M
Biomaterials
. 2022 Jan;
281:121342.
PMID: 34995903
Islet transplantation is a promising regenerative therapy that would reduce the dependence of type 1 diabetic patients on insulin injections. However, islet transplantation is not yet widely available, in part...
7.
Mahou R, Vlahos A, Shulman A, Sefton M
ACS Biomater Sci Eng
. 2021 Jan;
4(11):3704-3712.
PMID: 33429609
The lack of vascularization limits the creation of engineered tissue constructs with clinically relevant sizes. We pioneered a bottom-up process (modular tissue engineering) in which constructs with intrinsic vasculature were...
8.
Vlahos A, Talior-Volodarsky I, Kinney S, Sefton M
Biomaterials
. 2020 Nov;
269:120499.
PMID: 33168223
The subcutaneous space has been shown to be a suitable site for islet transplantation, however an abundance of islets is required to achieve normoglycemia, often requiring multiple donors. The loss...
9.
Vlahos A, Kinney S, Kingston B, Keshavjee S, Won S, Martyts A, et al.
Biomaterials
. 2020 Jan;
232:119710.
PMID: 31901691
Pancreatic islets are fragile cell clusters and many isolated islets are not suitable for transplantation. Furthermore, following transplantation, islets will experience a state of hypoxia and poor nutrient diffusion before...
10.