Alexander E Aleshin
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Explore the profile of Alexander E Aleshin including associated specialties, affiliations and a list of published articles.
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29
Citations
659
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Recent Articles
1.
Wu J, Baranowski M, Aleshin A, Isiorho E, Lambert L, De Backer L, et al.
ACS Omega
. 2025 Feb;
10(5):4912-4926.
PMID: 39959108
The human H1-related phosphatase (VHR; ) is a critical positive regulator of the innate immune response. Recent studies suggest that inhibiting VHR could be beneficial in treating sepsis and septic...
2.
Tian Y, Shin K, Aleshin A, Im W, Marassi F
Biophys J
. 2022 Sep;
121(20):3896-3906.
PMID: 36056555
The adaptability of proteins to their work environments is fundamental for cellular life. Here, we describe how the hemopexin-like domain of the multifunctional blood glycoprotein vitronectin binds Ca to adapt...
3.
Zhang L, Kent J, Whitaker M, Young D, Herrmann D, Aleshin A, et al.
Nat Commun
. 2022 Apr;
13(1):2255.
PMID: 35474308
Iron is essential for growth of Mycobacterium tuberculosis, the causative agent of tuberculosis. To acquire iron from the host, M. tuberculosis uses the siderophores called mycobactins and carboxymycobactins. Here, we...
4.
Aleshin A, Yao Y, Iftikhar A, Bobkov A, Yu J, Cadwell G, et al.
Structure
. 2021 Apr;
29(9):1029-1039.e3.
PMID: 33878292
PLEKHA7 (pleckstrin homology domain containing family A member 7) plays key roles in intracellular signaling, cytoskeletal organization, and cell adhesion, and is associated with multiple human cancers. The interactions of...
5.
Chen L, Aleshin A, Alitongbieke G, Zhou Y, Zhang X, Ye X, et al.
Nat Commun
. 2017 Jul;
8:16066.
PMID: 28714476
Retinoid X receptor-alpha (RXRα) binds to DNA either as homodimers or heterodimers, but it also forms homotetramers whose function is poorly defined. We previously discovered that an N-terminally-cleaved form of...
6.
Stanford S, Aleshin A, Zhang V, Ardecky R, Hedrick M, Zou J, et al.
Nat Chem Biol
. 2017 Mar;
13(6):624-632.
PMID: 28346406
Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase...
7.
Rozanov D, Cheltsov A, Sergienko E, Vasile S, Golubkov V, Aleshin A, et al.
PLoS One
. 2015 Jun;
10(6):e0129566.
PMID: 26075913
A high throughput screen for compounds that induce TRAIL-mediated apoptosis identified ML100 as an active chemical probe, which potentiated TRAIL activity in prostate carcinoma PPC-1 and melanoma MDA-MB-435 cells. Follow-up...
8.
Rodionova I, Zuccola H, Sorci L, Aleshin A, Kazanov M, Ma C, et al.
J Biol Chem
. 2015 Jan;
290(12):7693-706.
PMID: 25631047
Nicotinate mononucleotide adenylyltransferase NadD is an essential enzyme in the biosynthesis of the NAD cofactor, which has been implicated as a target for developing new antimycobacterial therapies. Here we report...
9.
Chen L, Wang Z, Aleshin A, Chen F, Chen J, Jiang F, et al.
Chem Biol
. 2014 Apr;
21(5):596-607.
PMID: 24704507
Retinoid X receptor-alpha (RXRα), an intriguing and unique drug target, can serve as an intracellular target mediating the anticancer effects of certain nonsteroidal anti-inflammatory drugs (NSAIDs), including sulindac. We report...
10.
Shiryaev S, Aleshin A, Muranaka N, Kukreja M, Routenberg D, Remacle A, et al.
FEBS J
. 2014 Apr;
281(11):2487-502.
PMID: 24698179
Bacteroides fragilis causes the majority of anaerobic infections in humans. The presence of a pathogenicity island in the genome discriminates pathogenic and commensal B. fragilis strains. The island encodes metalloproteinase...