Alexander D Bershadsky
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Explore the profile of Alexander D Bershadsky including associated specialties, affiliations and a list of published articles.
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51
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3224
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Recent Articles
1.
Aureille J, Prabhu S, Barnett S, Farrugia A, Arnal I, Lafanechere L, et al.
EMBO J
. 2024 May;
43(13):2715-2732.
PMID: 38769437
Microtubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood. Molecular complexes containing KANK family proteins connect microtubules...
2.
Lin S, Changede R, Farrugia A, Bershadsky A, Sheetz M, Prost J, et al.
Phys Rev Lett
. 2024 May;
132(18):188402.
PMID: 38759206
Cell adhesion receptors are transmembrane proteins that bind cells to their environment. These proteins typically cluster into disk-shaped or linear structures. Here, we show that such clustering patterns spontaneously emerge...
3.
Li W, Chung W, Kozlov M, Medalia O, Geiger B, Bershadsky A
Biophys J
. 2023 Jun;
122(18):3704-3721.
PMID: 37301982
Adherent filopodia are elongated finger-like membrane protrusions, extending from the edges of diverse cell types and participating in cell adhesion, spreading, migration, and environmental sensing. The formation and elongation of...
4.
Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives
Tee Y, Goh W, Yong X, Ong H, Hu J, Tay I, et al.
Nat Commun
. 2023 Feb;
14(1):776.
PMID: 36774346
Deviations from mirror symmetry in the development of bilateral organisms are common but the mechanisms of initial symmetry breaking are insufficiently understood. The actin cytoskeleton of individual cells self-organises in...
5.
Wang H, Hu J, Yi K, Ma Z, Song X, Lee Y, et al.
Curr Biol
. 2022 Aug;
32(18):4013-4024.e6.
PMID: 35981539
The first asymmetric meiotic cell divisions in mouse oocytes are driven by formin 2 (FMN2)-nucleated actin polymerization around the spindle. In this study, we investigated how FMN2 is recruited to...
6.
Efremov A, Yao M, Sun Y, Tee Y, Sheetz M, Bershadsky A, et al.
Biomaterials
. 2022 Apr;
284:121477.
PMID: 35395455
Filopodia are ubiquitous membrane projections that play crucial role in guiding cell migration on rigid substrates and through extracellular matrix by utilizing yet unknown mechanosensing molecular pathways. As recent studies...
7.
Nishimura Y, Shi S, Li Q, Bershadsky A, Viasnoff V
Cells Dev
. 2021 Aug;
168:203736.
PMID: 34455135
REF52 fibroblasts have a well-developed contractile machinery, the most prominent elements of which are actomyosin stress fibers with highly ordered organization of actin and myosin IIA filaments. The relationship between...
8.
Li W, Sancho A, Chung W, Vinik Y, Groll J, Zick Y, et al.
J Cell Sci
. 2021 Mar;
134(8).
PMID: 33722978
The mechanisms underlying the cellular response to extracellular matrices (ECMs) that consist of multiple adhesive ligands are still poorly understood. Here, we address this topic by monitoring specific cellular responses...
9.
Nishimura Y, Shi S, Zhang F, Liu R, Takagi Y, Bershadsky A, et al.
J Cell Sci
. 2021 Feb;
134(8).
PMID: 33589498
The small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell biological studies. It inhibits formin-driven actin polymerization in vitro, but not polymerization of pure actin. It...
10.
Rafiq N, Grenci G, Lim C, Kozlov M, Jones G, Viasnoff V, et al.
Philos Trans R Soc Lond B Biol Sci
. 2019 Aug;
374(1779):20180228.
PMID: 31431172
Podosomes are a singular category of integrin-mediated adhesions important in the processes of cell migration, matrix degradation and cancer cell invasion. Despite a wealth of biochemical studies, the effects of...