Alexander C Huang
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Explore the profile of Alexander C Huang including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Wang G, Lyudovyk O, Kim J, Lin Y, Elhanati Y, Mathew D, et al.
STAR Protoc
. 2023 May;
4(2):102289.
PMID: 37159385
The current abundance of immunotherapy clinical trials presents an opportunity to learn about the underlying mechanisms and pharmacodynamic effects of novel drugs on the human immune system. Here, we present...
12.
Painter M, Johnston T, Lundgreen K, Santos J, Qin J, Goel R, et al.
bioRxiv
. 2023 Feb;
PMID: 36798171
SARS-CoV-2 infection of vaccinated individuals is increasingly common but rarely results in severe disease, likely due to the enhanced potency and accelerated kinetics of memory immune responses. However, there have...
13.
Cosgriff C, Miano T, Mathew D, Huang A, Giannini H, Kuri-Cervantes L, et al.
Crit Care Explor
. 2022 Dec;
4(12):e0800.
PMID: 36479446
Design: Prospective observational cohort study. Setting: Two hospitals in the United States. Patients: One hundred sixty-seven hospitalized adults with COVID-19. Intervention: None. Measurements And Main Results: We measured 713 plasma...
14.
Giles J, Ngiow S, Manne S, Baxter A, Khan O, Wang P, et al.
Nat Immunol
. 2022 Oct;
23(11):1600-1613.
PMID: 36271148
Naïve CD8 T cells can differentiate into effector (T), memory (T) or exhausted (T) T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells...
15.
Herati R, Knorr D, Vella L, Silva L, Chilukuri L, Apostolidis S, et al.
Nat Immunol
. 2022 Jul;
23(8):1183-1192.
PMID: 35902637
Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell responses in patients with cancer but PD-1 is also expressed by other immune cells, including follicular helper CD4 T cells (Tfh) which...
16.
Ou L, Wang H, Huang H, Zhou Z, Lin Q, Guo Y, et al.
Clin Transl Med
. 2022 Jun;
12(6):e814.
PMID: 35731974
Background: Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory. Vδ2 T cells are unique to primates and few...
17.
Lyudovyk O, Kim J, Qualls D, Hwee M, Lin Y, Boutemine S, et al.
Cancer Cell
. 2022 Jun;
40(7):738-753.e5.
PMID: 35679859
How immune dysregulation affects recovery from COVID-19 infection in patients with cancer remains unclear. We analyzed cellular and humoral immune responses in 103 patients with prior COVID-19 infection, more than...
18.
Apostolidis S, Sarkar A, Giannini H, Goel R, Mathew D, Suzuki A, et al.
Front Immunol
. 2022 Mar;
13:834988.
PMID: 35309299
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been...
19.
Giles J, Manne S, Freilich E, Oldridge D, Baxter A, George S, et al.
Immunity
. 2022 Mar;
55(3):557-574.e7.
PMID: 35263570
The clinical benefit of T cell immunotherapies remains limited by incomplete understanding of T cell differentiation and dysfunction. We generated an epigenetic and transcriptional atlas of T cell differentiation from...
20.
Huang A, Zappasodi R
Nat Immunol
. 2022 Mar;
23(5):660-670.
PMID: 35241833
Ten years since the immune checkpoint inhibitor ipilimumab was approved for advanced melanoma, it is time to reflect on the lessons learned regarding modulation of the immune system to treat...