Sasikanth Manne
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Explore the profile of Sasikanth Manne including associated specialties, affiliations and a list of published articles.
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47
Citations
5921
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Recent Articles
1.
Huang Y, Ngiow S, Baxter A, Manne S, Park S, Wu J, et al.
Sci Immunol
. 2025 Mar;
10(105):eado3032.
PMID: 40053604
Although checkpoint blockade temporarily improves exhausted CD8 T (T) cell function, the underlying T epigenetic landscape remains largely unchanged, preventing durable T "reinvigoration" in cancer and chronic infections. The transcription...
2.
Wang K, Coutifaris P, Brocks D, Wang G, Azar T, Solis S, et al.
Cancer Cell
. 2024 Aug;
42(9):1582-1597.e10.
PMID: 39214097
Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans remains unclear. Here, we perform paired single-cell RNA and T ...
3.
Andrews L, Butler S, Cui J, Cillo A, Cardello C, Liu C, et al.
Cell
. 2024 Aug;
187(16):4355-4372.e22.
PMID: 39121848
Overcoming immune-mediated resistance to PD-1 blockade remains a major clinical challenge. Enhanced efficacy has been demonstrated in melanoma patients with combined nivolumab (anti-PD-1) and relatlimab (anti-LAG-3) treatment, the first in...
4.
Ngiow S, Manne S, Huang Y, Azar T, Chen Z, Mathew D, et al.
Cell
. 2024 Aug;
187(16):4336-4354.e19.
PMID: 39121847
Exhausted CD8 T (T) cells in chronic viral infection and cancer have sustained co-expression of inhibitory receptors (IRs). T cells can be reinvigorated by blocking IRs, such as PD-1, but...
5.
Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim S, et al.
Nat Immunol
. 2024 Jan;
25(3):577.
PMID: 38267693
No abstract available.
6.
Beltra J, Abdel-Hakeem M, Manne S, Zhang Z, Huang H, Kurachi M, et al.
Immunity
. 2023 Dec;
56(12):2699-2718.e11.
PMID: 38091951
Rewiring exhausted CD8 T (Tex) cells toward functional states remains a therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor Tox. However, epigenetic remodeling occurs as Tex cells...
7.
Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim S, et al.
Nat Immunol
. 2023 Oct;
24(11):1947-1959.
PMID: 37845489
Age-associated changes in the T cell compartment are well described. However, limitations of current single-modal or bimodal single-cell assays, including flow cytometry, RNA-seq (RNA sequencing) and CITE-seq (cellular indexing of...
8.
Wu J, Manne S, Ngiow S, Baxter A, Huang H, Freilich E, et al.
Sci Immunol
. 2023 Aug;
8(86):eade3369.
PMID: 37595022
Identifying molecular mechanisms of exhausted CD8 T cells (T) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation of in vivo T can be...
9.
Baxter A, Huang H, Giles J, Chen Z, Wu J, Drury S, et al.
Immunity
. 2023 Jun;
56(6):1320-1340.e10.
PMID: 37315535
CD8 T cell exhaustion (Tex) limits disease control during chronic viral infections and cancer. Here, we investigated the epigenetic factors mediating major chromatin-remodeling events in Tex-cell development. A protein-domain-focused in ...
10.
Wu J, Manne S, Ngiow S, Baxter A, Huang H, Freilich E, et al.
bioRxiv
. 2023 May;
PMID: 37131713
Identifying novel molecular mechanisms of exhausted CD8 T cells (T ) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation of T can be...