Alexander A Soukas
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Explore the profile of Alexander A Soukas including associated specialties, affiliations and a list of published articles.
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33
Citations
3197
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Recent Articles
11.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
12.
Pino E, Soukas A
Methods Mol Biol
. 2020 May;
2144:111-123.
PMID: 32410029
Gas chromatography-mass spectrometry (GC-MS) enables sensitive detection and relative quantification of fatty acids. In Caenorhabditis elegans, the use of GC-MS can corroborate findings from common staining methodologies, providing great resolution...
13.
Yu H, Rimbert A, Palmer A, Toyohara T, Xia Y, Xia F, et al.
Cell
. 2019 Nov;
179(6):1276-1288.e14.
PMID: 31778654
Although human genetic studies have implicated many susceptible genes associated with plasma lipid levels, their physiological and molecular functions are not fully characterized. Here we demonstrate that orphan G protein-coupled...
14.
Nhan J, Turner C, Anderson S, Yen C, Dalton H, Cheesman H, et al.
Proc Natl Acad Sci U S A
. 2019 Oct;
116(44):22322-22330.
PMID: 31611372
Early host responses toward pathogens are essential for defense against infection. In , the transcription factor, SKN-1, regulates cellular defenses during xenobiotic intoxication and bacterial infection. However, constitutive activation of...
15.
Soukas A, Hao H, Wu L
Trends Endocrinol Metab
. 2019 Aug;
30(10):745-755.
PMID: 31405774
Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes worldwide. Metformin also retards aging in model organisms and reduces the incidence of aging-related diseases such as...
16.
Zhou B, Soukas A
Autophagy
. 2019 Jul;
15(10):1852-1853.
PMID: 31313620
A wide variety of genetic, pharmacological and nutrient manipulations that extend lifespan in model organisms do so in a manner dependent upon increased autophagic flux. However, our recent findings suggest...
17.
Anderson S, Cheesman H, Peterson N, Salisbury J, Soukas A, Pukkila-Worley R
PLoS Pathog
. 2019 Jun;
15(6):e1007893.
PMID: 31206555
Fatty acids affect a number of physiological processes, in addition to forming the building blocks of membranes and body fat stores. In this study, we uncover a role for the...
18.
Soukas A, Zhou B
PLoS Biol
. 2019 May;
17(5):e3000285.
PMID: 31136567
Starvation is among the most ancient of selection pressures, driving evolution of a robust arsenal of starvation survival defenses. In order to survive starvation stress, organisms must be able to...
19.
Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer K, Cedillo L, et al.
Cell
. 2019 Apr;
177(2):299-314.e16.
PMID: 30929899
Autophagy is required in diverse paradigms of lifespan extension, leading to the prevailing notion that autophagy is beneficial for longevity. However, why autophagy is harmful in certain contexts remains unexplained....
20.
Yerevanian A, Soukas A
Curr Obes Rep
. 2019 Mar;
8(2):156-164.
PMID: 30874963
Purpose Of Review: Metformin has multiple benefits for health beyond its anti-hyperglycemic properties. The purpose of this manuscript is to review the mechanisms that underlie metformin's effects on obesity. Recent...